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In vitro Estrogenicity of Resin Composites
Previously, we have reported that sealants incorporating bisphenol A dimethacrylate showed estrogenicity by a reporter gene assay. This study tested the hypothesis that commercial composites, which contain various monomers and additives, exhibit estrogenic activity in vitro. The estrogenic activitie...
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| Published in: | Journal of dental research 2004-03, Vol.83 (3), p.222-226 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c395t-4794e6227d51f8f56fe8496703cb74206772683d7d1f7ead9207b33d9685941a3 |
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| cites | cdi_FETCH-LOGICAL-c395t-4794e6227d51f8f56fe8496703cb74206772683d7d1f7ead9207b33d9685941a3 |
| container_end_page | 226 |
| container_issue | 3 |
| container_start_page | 222 |
| container_title | Journal of dental research |
| container_volume | 83 |
| creator | Wada, H. Tarumi, H. Imazato, S. Narimatsu, M. Ebisu, S. |
| description | Previously, we have reported that sealants incorporating bisphenol A dimethacrylate
showed estrogenicity by a reporter gene assay. This study tested the hypothesis that
commercial composites, which contain various monomers and additives, exhibit
estrogenic activity in vitro. The estrogenic activities
of eluates obtained from 24 composites and 18 chemicals identified from the
composites tested were examined with the use of the reporter gene assay. Among the 24
composites, 6 products were estrogenic, and among the 18 constituents, 1
photostabilizer, 2-hydroxy-4-methoxy-benzophenone (HMBP), 1 photoinitiator,
2,2-dimethoxy-2-phenyl-acetophenone (DMPA), and 1 inhibitor, 2,6-di-tert-butyl-p-cresol (BHT) had
significant estrogenic activity. The concentration of HMBP in 4 estrogenic eluates
was greater than the minimum concentration required for estrogenicity, and DMPA was
found at a higher level than the minimum estrogenic concentration in the remaining 2
estrogenic specimens. These results suggest that the observed estrogenic activity of
6 composites is associated with the elution of either HMBP or DMPA. |
| doi_str_mv | 10.1177/154405910408300307 |
| format | article |
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showed estrogenicity by a reporter gene assay. This study tested the hypothesis that
commercial composites, which contain various monomers and additives, exhibit
estrogenic activity in vitro. The estrogenic activities
of eluates obtained from 24 composites and 18 chemicals identified from the
composites tested were examined with the use of the reporter gene assay. Among the 24
composites, 6 products were estrogenic, and among the 18 constituents, 1
photostabilizer, 2-hydroxy-4-methoxy-benzophenone (HMBP), 1 photoinitiator,
2,2-dimethoxy-2-phenyl-acetophenone (DMPA), and 1 inhibitor, 2,6-di-tert-butyl-p-cresol (BHT) had
significant estrogenic activity. The concentration of HMBP in 4 estrogenic eluates
was greater than the minimum concentration required for estrogenicity, and DMPA was
found at a higher level than the minimum estrogenic concentration in the remaining 2
estrogenic specimens. These results suggest that the observed estrogenic activity of
6 composites is associated with the elution of either HMBP or DMPA.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/154405910408300307</identifier><identifier>PMID: 14981123</identifier><identifier>CODEN: JDREAF</identifier><language>eng</language><publisher>United States: SAGE Publications</publisher><subject>Acetophenones - analysis ; Acetophenones - pharmacology ; Analysis of Variance ; Benzophenones - analysis ; Benzophenones - pharmacology ; Butylated Hydroxytoluene - analysis ; Butylated Hydroxytoluene - pharmacology ; Cell Line ; Chromatography, High Pressure Liquid ; Composite Resins - analysis ; Composite Resins - pharmacology ; Dentistry ; Estrogens - agonists ; Genes, Reporter - genetics ; Humans ; Plasmids ; Receptors, Estrogen - agonists ; Transfection</subject><ispartof>Journal of dental research, 2004-03, Vol.83 (3), p.222-226</ispartof><rights>International and American Associations for Dental Research</rights><rights>Copyright American Association for Dental Research/American Academy of Implant Dentistry Mar 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-4794e6227d51f8f56fe8496703cb74206772683d7d1f7ead9207b33d9685941a3</citedby><cites>FETCH-LOGICAL-c395t-4794e6227d51f8f56fe8496703cb74206772683d7d1f7ead9207b33d9685941a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14981123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wada, H.</creatorcontrib><creatorcontrib>Tarumi, H.</creatorcontrib><creatorcontrib>Imazato, S.</creatorcontrib><creatorcontrib>Narimatsu, M.</creatorcontrib><creatorcontrib>Ebisu, S.</creatorcontrib><title>In vitro Estrogenicity of Resin Composites</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>Previously, we have reported that sealants incorporating bisphenol A dimethacrylate
showed estrogenicity by a reporter gene assay. This study tested the hypothesis that
commercial composites, which contain various monomers and additives, exhibit
estrogenic activity in vitro. The estrogenic activities
of eluates obtained from 24 composites and 18 chemicals identified from the
composites tested were examined with the use of the reporter gene assay. Among the 24
composites, 6 products were estrogenic, and among the 18 constituents, 1
photostabilizer, 2-hydroxy-4-methoxy-benzophenone (HMBP), 1 photoinitiator,
2,2-dimethoxy-2-phenyl-acetophenone (DMPA), and 1 inhibitor, 2,6-di-tert-butyl-p-cresol (BHT) had
significant estrogenic activity. The concentration of HMBP in 4 estrogenic eluates
was greater than the minimum concentration required for estrogenicity, and DMPA was
found at a higher level than the minimum estrogenic concentration in the remaining 2
estrogenic specimens. These results suggest that the observed estrogenic activity of
6 composites is associated with the elution of either HMBP or DMPA.</description><subject>Acetophenones - analysis</subject><subject>Acetophenones - pharmacology</subject><subject>Analysis of Variance</subject><subject>Benzophenones - analysis</subject><subject>Benzophenones - pharmacology</subject><subject>Butylated Hydroxytoluene - analysis</subject><subject>Butylated Hydroxytoluene - pharmacology</subject><subject>Cell Line</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Composite Resins - analysis</subject><subject>Composite Resins - pharmacology</subject><subject>Dentistry</subject><subject>Estrogens - agonists</subject><subject>Genes, Reporter - genetics</subject><subject>Humans</subject><subject>Plasmids</subject><subject>Receptors, Estrogen - agonists</subject><subject>Transfection</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kE9Lw0AQxRdRbK1-AQ8SPHgQYmf2T3b3KKVqoSCInpc02S1bmmzNJkK_vQktCApeZmD4vTePR8g1wgOilFMUnIPQCBwUA2AgT8h4OKbD9ZSMAShNgXExIhcxbgBQU8XOyQi5VoiUjcn9ok6-fNuEZB77uba1L3y7T4JL3mz0dTIL1S5E39p4Sc5cvo326rgn5ONp_j57SZevz4vZ4zItmBZtyqXmNqNUlgKdciJzVnGdSWDFSnIKmZQ0U6yUJTpp81JTkCvGSp0poTnmbELuDr67Jnx2Nram8rGw221e29BFowBVplD04O0vcBO6pu6zGQp6yAG6h-gBKpoQY2Od2TW-ypu9QTBDjeZvjb3o5ujcrSpb_kiOvfXA9ADEfG1_3v5j-Q1oo3a2</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Wada, H.</creator><creator>Tarumi, H.</creator><creator>Imazato, S.</creator><creator>Narimatsu, M.</creator><creator>Ebisu, S.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>In vitro Estrogenicity of Resin Composites</title><author>Wada, H. ; 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showed estrogenicity by a reporter gene assay. This study tested the hypothesis that
commercial composites, which contain various monomers and additives, exhibit
estrogenic activity in vitro. The estrogenic activities
of eluates obtained from 24 composites and 18 chemicals identified from the
composites tested were examined with the use of the reporter gene assay. Among the 24
composites, 6 products were estrogenic, and among the 18 constituents, 1
photostabilizer, 2-hydroxy-4-methoxy-benzophenone (HMBP), 1 photoinitiator,
2,2-dimethoxy-2-phenyl-acetophenone (DMPA), and 1 inhibitor, 2,6-di-tert-butyl-p-cresol (BHT) had
significant estrogenic activity. The concentration of HMBP in 4 estrogenic eluates
was greater than the minimum concentration required for estrogenicity, and DMPA was
found at a higher level than the minimum estrogenic concentration in the remaining 2
estrogenic specimens. These results suggest that the observed estrogenic activity of
6 composites is associated with the elution of either HMBP or DMPA.</abstract><cop>United States</cop><pub>SAGE Publications</pub><pmid>14981123</pmid><doi>10.1177/154405910408300307</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-0345 |
| ispartof | Journal of dental research, 2004-03, Vol.83 (3), p.222-226 |
| issn | 0022-0345 1544-0591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80186815 |
| source | Sage Journals Online |
| subjects | Acetophenones - analysis Acetophenones - pharmacology Analysis of Variance Benzophenones - analysis Benzophenones - pharmacology Butylated Hydroxytoluene - analysis Butylated Hydroxytoluene - pharmacology Cell Line Chromatography, High Pressure Liquid Composite Resins - analysis Composite Resins - pharmacology Dentistry Estrogens - agonists Genes, Reporter - genetics Humans Plasmids Receptors, Estrogen - agonists Transfection |
| title | In vitro Estrogenicity of Resin Composites |
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