Alzheimer's Disease and Transmissible Virus Dementia (Creutzfeldt-Jakob Disease)

Ample justification exists on clinical, pathologic, and biologic grounds for considering a similar pathogenesis for AD and the spongiform virus encephalopathies. However, the crux of the comparison rests squarely on results of attempts to transmit AD to experimental animals, and these results have n...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1982-01, Vol.396 (1), p.131-143
Main Authors: BROWN, PAUL, SALAZAR, ANDRES M., GIBBS JR, CLARENCE J., GAJDUSEK, D. CARLETON
Format: Article
Language:English
Subjects:
Adult
Aged
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Alzheimer Disease - transmission
Animals
Autopsy
Biopsy
Brain - pathology
Creutzfeldt-Jakob Syndrome - genetics
Creutzfeldt-Jakob Syndrome - pathology
Creutzfeldt-Jakob Syndrome - transmission
Dementia - pathology
Female
Humans
Male
Middle Aged
Primates
Scrapie - pathology
Sheep
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Description
Summary:Ample justification exists on clinical, pathologic, and biologic grounds for considering a similar pathogenesis for AD and the spongiform virus encephalopathies. However, the crux of the comparison rests squarely on results of attempts to transmit AD to experimental animals, and these results have not as yet validated a common etiology. Investigations of the biologic similarities between AD and the spongiform virus encephalopathies proceed in several laboratories, and our own observation of inoculated animals will be continued in the hope that incubation periods for AD may be even longer than those of CJD.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1982.tb26849.x