Theophylline-controlled release preparations and fatty food : an in vitro study using the rotating dialysis cell method

The in vitro dissolution behavior of four controlled-release theophylline products was investigated utilizing the rotating dialysis cell method. The effects of pH, oil, and enzymes on the dissolution profiles were studied. The wide range of pH values and the content of oil and enzymes in the dissolu...

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Bibliographic Details
Published in:Pharmaceutical research 1990-11, Vol.7 (11), p.1134-1140
Main Authors: EL-ARINI, S. K, SHIU, G. K, SKELLY, J. P
Format: Article
Language:English
Subjects:
Bile Acids and Salts - analysis
Biological and medical sciences
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Delayed-Action Preparations
Dietary Fats
Food
General pharmacology
Hydrogen-Ion Concentration
Medical sciences
Peanut Oil
Pepsin A
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Plant Oils
Solubility
Theophylline - administration & dosage
Theophylline - chemistry
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Summary:The in vitro dissolution behavior of four controlled-release theophylline products was investigated utilizing the rotating dialysis cell method. The effects of pH, oil, and enzymes on the dissolution profiles were studied. The wide range of pH values and the content of oil and enzymes in the dissolution media in the dialysis cell, which functioned as an in vitro model, were simulated to mimic physiological changes due to food along the entire gastrointestinal tract. Treatment with oil affected the dissolution behavior of Uniphyl and especially Theo-Dur Sprinkle but had little or no effect on the dissolution profiles of Theo-Dur tablets and Theo-24 capsules. The in vitro observations of the oil effect were related to the food effect obtained from published in vivo studies. The rotating dialysis cell can be a useful tool in studying factors which may be responsible for dissolution-related food effects on the absorption of controlled-release products.
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1015976108251