Origin of phenotypic variation in clones of simian virus 40-transformed mouse embryo cells

The present study demonstrates that cloned mouse embryo cell populations, mainly fibroblastic in morphology, differ in biological behavior. Certain of these characteristics are transmitted to their SV40-transformed progeny, leading to significant differences between groups of transformed clones deri...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1983-04, Vol.43 (4), p.1835-1841
Main Authors: Omar, R A, Lanks, K W
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion
Cell Cycle - drug effects
Cell Line
Cell Transformation, Viral
Clone Cells
Embryo, Mammalian
Fibroblast Growth Factors
Genetic Variation
Mice
Mice, Inbred BALB C
Peptides - pharmacology
Phenotype
Simian virus 40 - genetics
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Summary:The present study demonstrates that cloned mouse embryo cell populations, mainly fibroblastic in morphology, differ in biological behavior. Certain of these characteristics are transmitted to their SV40-transformed progeny, leading to significant differences between groups of transformed clones derived from single normal parental clones. This is true not only of parameters that can be easily observed in the normal cells but also of characteristics generally thought to be unique to the transformed phenotype, e.g., anchorage-independent growth. Thus, these findings establish parental phenotype as an important source of variation in transformed populations and indicate that cloned normal cells should be used whenever possible in studies of oncogenic tranformation.
ISSN:0008-5472