A novel treatment for ischemic intracranial hypertension in cats

There is no accepted efficacious treatment for ischemic cerebral edema. We show in a cat model of focal cerebral ischemia that infarct volume can be reduced (p less than 0.05) by ventriculocisternal perfusion with an oxygenated fluorochemical emulsion (bis-perfluorobutylethylene). An accompanying ef...

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Bibliographic Details
Published in:Stroke (1970) 1991, Vol.22 (1), p.80-83
Main Authors: BELL, R. D, FRAZER, G. D, OSTERHOLM, J. L, DUCKETT, S. W
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - pathology
Brain Ischemia - physiopathology
Cardiovascular system
Cats
Cerebral Infarction - pathology
Fluorocarbons - pharmacology
Intracranial Pressure
Male
Medical sciences
Perfusion
Pharmacology. Drug treatments
Staining and Labeling
Tetrazolium Salts
Vasodilator agents. Cerebral vasodilators
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Summary:There is no accepted efficacious treatment for ischemic cerebral edema. We show in a cat model of focal cerebral ischemia that infarct volume can be reduced (p less than 0.05) by ventriculocisternal perfusion with an oxygenated fluorochemical emulsion (bis-perfluorobutylethylene). An accompanying effect of such ventriculocisternal perfusion is a reduction in intracranial pressure. At 18 hours following the start of the perfusion, there was a significant (p less than 0.05) difference in intracranial pressure between nonperfused controls (mean 11.4 [range 2.3-23.0] torr, n = 6) and cats perfused with an oxygenated nutrient solution not containing fluorochemical (mean 11.3 [range 3.0-29.0] torr, n = 8) or animals perfused with the oxygenated fluorochemical emulsion (mean 2.21 [range 0-3.5] torr, n = 7). Perfusion with this oxygenated fluorochemical emulsion warrants further study as a treatment for elevated intracranial pressure.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.22.1.80