Interleukin-4: A Prototypic Immunoregulatory Lymphokine

THE IMMUNE RESPONSE involves the participation of a large number of distinct cell types whose functions must be coordinated to insure a response that is appropriate in quality and in magnitude to the eliciting antigenic stimulus. This coordination of function is generally believed to be regulated by...

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Bibliographic Details
Published in:Blood 1991-05, Vol.77 (9), p.1859-1870
Main Author: Paul, William E.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Biological and medical sciences
Chromosome Mapping
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunity
Immunobiology
Interleukin-4 - biosynthesis
Interleukin-4 - chemistry
Interleukin-4 - genetics
Interleukin-4 - physiology
Receptors, Interleukin-4
Receptors, Mitogen - genetics
Receptors, Mitogen - metabolism
T-Lymphocytes - cytology
T-Lymphocytes - immunology
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Summary:THE IMMUNE RESPONSE involves the participation of a large number of distinct cell types whose functions must be coordinated to insure a response that is appropriate in quality and in magnitude to the eliciting antigenic stimulus. This coordination of function is generally believed to be regulated by the action of T lymphocytes, whose receptors are specific for peptides derived from the eliciting antigen, bound to a groove in a class I or a class II major histocompatibility complex (MHC) molecule. Much of the regulatory function of such T cells is mediated by the secretion of a set of potent polypeptides often designated as lymphokines or interleukins (ILs).1 Those that appear to be principally secreted by immunocompetent cells in response to the interaction of antigen with a specific receptor are listed in Table 1. I will refer to these molecules as “immune recognition-induced lymphokines.”
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V77.9.1859.1859