Antidiabetic Behavior of Biguanides

The existence of active electron pairs on some nitrogen atoms in phenformin hydrochloride is inferred from the presence of a hydrogen catalytic polarographic wave. This finding emphasizes the ability of biguanides to form hydrogen bridges with other molecular species such as amino acids and proteins...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1983-05, Vol.72 (5), p.565-567
Main Authors: Vicente-Pedrós, F., Monge, J. Trejueque, Vert, F. Tomás
Format: Article
Language:English
Subjects:
Biguanides - pharmacology
Chemical Phenomena
Chemistry, Physical
determination by polarography
effect of phenformin determination by polarography
Hydrogen-Ion Concentration
Hypoglycemic Agents
Insulin - metabolism
Insulin-complexation with zinc in vivo
Insulin–complexation with zinc in vivo, effect of phenformin determination by polarograph
Insulin—complexation with zinc in vivo, effect of phenformin determination by polarography
Phenformin - metabolism
Phenformin-effect on insulin-zinc complexes
Phenformin–effect on insulin-zinc complexes, determination by polarography
Polarography - methods
Polarography-determination of effect of phenformin on insulin-zinc complexes
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Summary:The existence of active electron pairs on some nitrogen atoms in phenformin hydrochloride is inferred from the presence of a hydrogen catalytic polarographic wave. This finding emphasizes the ability of biguanides to form hydrogen bridges with other molecular species such as amino acids and proteins, as well as to form coordination complexes with zinc and other metallic cations by means of these electron pairs. The antidiabetic action of phenformin and other related biguanides can be explained in terms of competition between these molecules and insulin to coordinate cationic oligoelements together with their ability to form hydrogen bonds between the biguanide moiety and insulin itself.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600720524