Model selection for the adsorption of phenobarbital by activated charcoal

Activated charcoal is known to adsorb a wide variety of substances from solution, and several equations have been used to fit the resulting adsorption data. The determination of the correct model to fit phenobarbital adsorption onto activated charcoal was made using a calorimetric method. The differ...

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Bibliographic Details
Published in:Pharmaceutical research 1991-02, Vol.8 (2), p.228-231
Main Authors: BURKE, G. M, WURSTER, D. E, BURAPHACHEEP, V, BERG, M. J, VENG-PEDERSEN, P, SCHOTTELIUS, D. D
Format: Article
Language:English
Subjects:
Adsorption
Biological and medical sciences
Charcoal
Drug toxicity and drugs side effects treatment
Hot Temperature
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Models, Theoretical
Pharmacology. Drug treatments
Phenobarbital
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Summary:Activated charcoal is known to adsorb a wide variety of substances from solution, and several equations have been used to fit the resulting adsorption data. The determination of the correct model to fit phenobarbital adsorption onto activated charcoal was made using a calorimetric method. The differential heats of displacement of water by phenobarbital for four activated charcoals were determined and found to be linearly related to the amount of phenobarbital adsorbed. The activated charcoals studied had statistically similar heats of displacement. The linear relationship between heat evolved and the amount of phenobarbital adsorbed is consistent with the assumptions implicit in the Langmuir model.
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1015800322286