The Immune Response Evokes Changes in Brain Noradrenergic Neurons

A decreased noradrenaline turnover in the hypothalami of rats was observed at the peak of the immune response to sheep red blood cells. The decrease in noradrenergic neuronal activity was mimicked by injection of soluble mediators released by immunological cells activated in vitro. Noradrenaline als...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1983-08, Vol.221 (4610), p.564-566
Main Authors: Besedovsky, Hugo, Del Rey, Adriana, Sorkin, Ernst, Da Prada, Mosé, Burri, Roland, Honegger, Conrad
Format: Article
Language:English
Subjects:
Adrenergic neurons
Analysis of the immune response. Humoral and cellular immunity
Animals
Biological and medical sciences
Brain
Brain - immunology
Brain - physiology
Brain stem
Brain Stem - immunology
Brain Stem - physiology
Cell interactions
Cell research
Central nervous system
Cytological research
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hypothalamus
Hypothalamus - immunology
Hypothalamus - physiology
Immune response
Immunity
Immunobiology
Immunology
Neurobiology
Neurons
Norepinephrine - physiology
Observations
Rats
Sheep - immunology
Spleen
Spleen - immunology
Spleen - physiology
Transponders
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Summary:A decreased noradrenaline turnover in the hypothalami of rats was observed at the peak of the immune response to sheep red blood cells. The decrease in noradrenergic neuronal activity was mimicked by injection of soluble mediators released by immunological cells activated in vitro. Noradrenaline also tended to decrease in the brainstem but not in the residual brain. It is suggested that products released from activated immunological cells during the immune response may induce the previously described autonomic and endocrine mechanisms that contribute to immunoregulation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6867729