Immune suppression and histophysiology of the immune response. I. Cortisone acetate and lymphoid cell migration

Seven daily intramuscular (im) injections of cortisone acetate (25 mg/Kg b.w.) given to rats or rabbits produced, (i) a pronounced reduction in the numbers of small lymphocytes in thymus-independent areas, (ii) atrophy of the thymic cortex, (iii) atrophy of germinal centres and (iv) a consequent dep...

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Bibliographic Details
Published in:Virchows Archiv. B, Cell pathology Cell pathology, 1983, Vol.43 (1), p.43-54
Main Authors: Van den Broek, A A, Keuning, F J, Soeharto, R, Prop, N
Format: Article
Language:English
Subjects:
Animals
Atrophy
B-Lymphocytes
Cell Movement - drug effects
Cortisone - analogs & derivatives
Cortisone - pharmacology
Immune Tolerance - drug effects
Immunization
Immunosuppression
Lymphocytes - drug effects
Rabbits
Rats
T-Lymphocytes
Thymus Gland - drug effects
Thymus Gland - pathology
Whole-Body Irradiation
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Summary:Seven daily intramuscular (im) injections of cortisone acetate (25 mg/Kg b.w.) given to rats or rabbits produced, (i) a pronounced reduction in the numbers of small lymphocytes in thymus-independent areas, (ii) atrophy of the thymic cortex, (iii) atrophy of germinal centres and (iv) a consequent depressed production of germinal centre-derived cells. Lymphocyte depletion was not caused by cell lysis. Moreover cell traffic between peripheral lymphoid organs did not seem to be altered. A revival of the depressed germinal centres in cortisone-treated (inbred) rats could be achieved by a transfer of bone-marrow cell suspensions from normal, cortisone-treated or T-cell-deprived animals. It was concluded that cortisone acetate arrests the migration of B-lymphocytes from the bone marrow to germinal centres in peripheral lymphoid organs, and that the accumulations of lymphoid cells in the bone marrow of cortison-treated animals might be composed of immature or mature T- and B-lymphocytes.
ISSN:0340-6075