Control of Acute Lower Respiratory Illness in the Developing World: An Assessment of Vaccine Intervention

The major bacterial and viral causes of morbidity and death due to acute lower respiratory infection (ALRI) in the developing world are amenable to control by vaccines. Initially, full use of measles, pertussis, and diphtheria vaccines, in appropriately scheduled programs, can make an immediate cont...

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Bibliographic Details
Published in:Reviews of infectious diseases 1991-05, Vol.13, p.S571-S577
Main Author: Karzon, David T.
Format: Article
Language:English
Subjects:
Acute Disease
Antibodies
Bacterial diseases
Bacterial diseases of the respiratory system
Bacterial Infections - prevention & control
Bacterial Vaccines
Biological and medical sciences
Child, Preschool
Developing Countries
Epidemiology
Human bacterial diseases
Humans
Immunization
Infant
Infections
Infectious diseases
Measles
Medical sciences
Prevention with Use of Vaccines
Respiratory tract infections
Respiratory Tract Infections - prevention & control
Risk Factors
Tropical medicine
Vaccination
Viral Vaccines
Virus Diseases - prevention & control
Viruses
Whooping cough
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Summary:The major bacterial and viral causes of morbidity and death due to acute lower respiratory infection (ALRI) in the developing world are amenable to control by vaccines. Initially, full use of measles, pertussis, and diphtheria vaccines, in appropriately scheduled programs, can make an immediate contribution to the reduction of severe respiratory infection. Emerging technologies offer the promise of vaccines against bacterial and viral respiratory pathogens that are suitable for infants and children in developing countries. These technologic advances include the use of protein-polysaccharide conjugates of endemic serotypes for Haemophilus influenzae and Streptococcus pneumoniae vaccines and new approaches to the use of purified protein components or attenuated live virus with respiratory syncytial virus and paramyxovirus vaccines. Such vaccines should soon be available for evaluation in developing countries. It is timely to embark upon a program of development, evaluation, and worldwide deployment of vaccines for the control of ALRI.
ISSN:0162-0886