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Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval
Objectives To optimize empirical treatment of urinary tract infections (UTIs), regular evaluation of the antibiotic susceptibility of the most common uropathogen, Escherichia coli, is necessary. We compared the antibiotic prescription rate for UTIs in women and the E. coli antibiotic susceptibility...
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| Published in: | Journal of antimicrobial chemotherapy 2010-10, Vol.65 (10), p.2128-2133 |
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| container_end_page | 2133 |
| container_issue | 10 |
| container_start_page | 2128 |
| container_title | Journal of antimicrobial chemotherapy |
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| creator | den Heijer, C. D. J. Donker, G. A. Maes, J. Stobberingh, E. E. |
| description | Objectives To optimize empirical treatment of urinary tract infections (UTIs), regular evaluation of the antibiotic susceptibility of the most common uropathogen, Escherichia coli, is necessary. We compared the antibiotic prescription rate for UTIs in women and the E. coli antibiotic susceptibility results, including the prevalence of extended-spectrum β-lactamase (ESBL)-producing strains, in 2009 with data collected 5 years earlier. Patients and methods Urinary samples from female patients with symptoms of uncomplicated UTI in 42 general practices were collected over a 6 month period. Uropathogens were identified and the antibiotic susceptibility of E. coli was determined. Results We analysed 970 urine cultures, of which 785 (81%) were considered positive (≥103 cfu/mL). E. coli accounted for 72% of the isolates. ESBLs showed an increase between the two surveys (0.1% versus 1%; P |
| doi_str_mv | 10.1093/jac/dkq286 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_807280116</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>807280116</sourcerecordid><originalsourceid>FETCH-LOGICAL-c449t-3dca695e20d78ade63133568849c86243e2ce009c1f0ba8ecc33972ebfa99cb53</originalsourceid><addsrcrecordid>eNqF0t9r1TAUB_AiirtOX_wDJAgiCN3yo0lb38budLKBL1cQX0KantrcpU2XpJv3H_LvNOVeJ-zFpxDyyTmcfJNlrwk-Ibhmp1ulT9ubW1qJJ9mKFALnFNfkabbCDPO8LDg7yl6EsMUYCy6q59kRxaKiXPBV9vtsjKYxLhqNwhw0TMvWmrhDrkPzGMCCjtCi2btJxd79hDHRi6B78Eb3RiHtrEGddwPqYFAW0HqOukcJglcWTV7pVB1Qum5gjOEjWu4Mk_ImuHFpE-9dau7vYBfQvYl9AhztQHlkxgj-TtmX2bNO2QCvDutx9u3Txeb8Mr_--vnL-dl1rouijjlrtRI1B4rbslItCEYYSyNXRa0rQQsGVAPGtSYdblQFWjNWlxSaTtW1bjg7zt7v607e3c4QohxMehRr1QhuDrLCJa0wIeK_suSclJSIKsm3j-TWzX5MYyyoIEsSCX3YI-1dCB46OXkzKL-TBMslZZlSlvuUE35zqDg3A7QP9G-sCbw7ABW0sp1Xozbhn2OM4PQtksv3zoQIvx7Olb-RomQll5fff0i83hT06moj1-wP3wrCpA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>755418256</pqid></control><display><type>article</type><title>Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval</title><source>Oxford Journals Online</source><creator>den Heijer, C. D. J. ; Donker, G. A. ; Maes, J. ; Stobberingh, E. E.</creator><creatorcontrib>den Heijer, C. D. J. ; Donker, G. A. ; Maes, J. ; Stobberingh, E. E.</creatorcontrib><description>Objectives To optimize empirical treatment of urinary tract infections (UTIs), regular evaluation of the antibiotic susceptibility of the most common uropathogen, Escherichia coli, is necessary. We compared the antibiotic prescription rate for UTIs in women and the E. coli antibiotic susceptibility results, including the prevalence of extended-spectrum β-lactamase (ESBL)-producing strains, in 2009 with data collected 5 years earlier. Patients and methods Urinary samples from female patients with symptoms of uncomplicated UTI in 42 general practices were collected over a 6 month period. Uropathogens were identified and the antibiotic susceptibility of E. coli was determined. Results We analysed 970 urine cultures, of which 785 (81%) were considered positive (≥103 cfu/mL). E. coli accounted for 72% of the isolates. ESBLs showed an increase between the two surveys (0.1% versus 1%; P < 0.001), while no difference in antibiotic susceptibility to the commonly used antimicrobial agents for UTIs was observed. A significantly lower susceptibility rate to co-amoxiclav was observed in the eastern region of the Netherlands, as compared with the northern region (80% versus 92%; P < 0.05). Consistent with national guidelines, the prescription rate of trimethoprim decreased over time (19% versus 5%; P < 0.05) whereas nitrofurantoin and fosfomycin rates showed an increase (58% versus 66% and 0% versus 6% respectively, both P < 0.05). Conclusions Over a 5 year period, the antibiotic susceptibility of uropathogenic E. coli did not change in female patients with uncomplicated UTI in the Netherlands, but ESBL prevalence increased. With respect to the prescription of antimicrobial agents, compliance with national UTI guidelines was good.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkq286</identifier><identifier>PMID: 20682565</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - pharmacology ; antibiotic use ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobial agents ; antimicrobial resistance ; Bacterial diseases ; Bacterial diseases of the urinary system ; Biological and medical sciences ; Child ; community-acquired ; Comparative analysis ; cystitis ; Drug Prescriptions - standards ; Drug Prescriptions - statistics & numerical data ; Drug Utilization - statistics & numerical data ; E coli ; ESBLs ; Escherichia coli ; Escherichia coli Infections - microbiology ; Female ; General Practice ; Guideline Adherence - statistics & numerical data ; Human bacterial diseases ; Humans ; Infectious diseases ; Medical sciences ; Microbial Sensitivity Tests ; Middle Aged ; Nephrology. Urinary tract diseases ; Netherlands ; Pathogens ; Pharmacology. Drug treatments ; Prescriptions ; Time Factors ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract diseases ; Urinary Tract Infections - microbiology ; Urinary tract. Prostate gland ; Uropathogenic Escherichia coli - drug effects ; Uropathogenic Escherichia coli - isolation & purification ; Women ; Young Adult</subject><ispartof>Journal of antimicrobial chemotherapy, 2010-10, Vol.65 (10), p.2128-2133</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Oct 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-3dca695e20d78ade63133568849c86243e2ce009c1f0ba8ecc33972ebfa99cb53</citedby><cites>FETCH-LOGICAL-c449t-3dca695e20d78ade63133568849c86243e2ce009c1f0ba8ecc33972ebfa99cb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23310453$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20682565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>den Heijer, C. D. J.</creatorcontrib><creatorcontrib>Donker, G. A.</creatorcontrib><creatorcontrib>Maes, J.</creatorcontrib><creatorcontrib>Stobberingh, E. E.</creatorcontrib><title>Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Objectives To optimize empirical treatment of urinary tract infections (UTIs), regular evaluation of the antibiotic susceptibility of the most common uropathogen, Escherichia coli, is necessary. We compared the antibiotic prescription rate for UTIs in women and the E. coli antibiotic susceptibility results, including the prevalence of extended-spectrum β-lactamase (ESBL)-producing strains, in 2009 with data collected 5 years earlier. Patients and methods Urinary samples from female patients with symptoms of uncomplicated UTI in 42 general practices were collected over a 6 month period. Uropathogens were identified and the antibiotic susceptibility of E. coli was determined. Results We analysed 970 urine cultures, of which 785 (81%) were considered positive (≥103 cfu/mL). E. coli accounted for 72% of the isolates. ESBLs showed an increase between the two surveys (0.1% versus 1%; P < 0.001), while no difference in antibiotic susceptibility to the commonly used antimicrobial agents for UTIs was observed. A significantly lower susceptibility rate to co-amoxiclav was observed in the eastern region of the Netherlands, as compared with the northern region (80% versus 92%; P < 0.05). Consistent with national guidelines, the prescription rate of trimethoprim decreased over time (19% versus 5%; P < 0.05) whereas nitrofurantoin and fosfomycin rates showed an increase (58% versus 66% and 0% versus 6% respectively, both P < 0.05). Conclusions Over a 5 year period, the antibiotic susceptibility of uropathogenic E. coli did not change in female patients with uncomplicated UTI in the Netherlands, but ESBL prevalence increased. With respect to the prescription of antimicrobial agents, compliance with national UTI guidelines was good.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antibiotic use</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobial agents</subject><subject>antimicrobial resistance</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the urinary system</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>community-acquired</subject><subject>Comparative analysis</subject><subject>cystitis</subject><subject>Drug Prescriptions - standards</subject><subject>Drug Prescriptions - statistics & numerical data</subject><subject>Drug Utilization - statistics & numerical data</subject><subject>E coli</subject><subject>ESBLs</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Female</subject><subject>General Practice</subject><subject>Guideline Adherence - statistics & numerical data</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Netherlands</subject><subject>Pathogens</subject><subject>Pharmacology. Drug treatments</subject><subject>Prescriptions</subject><subject>Time Factors</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract diseases</subject><subject>Urinary Tract Infections - microbiology</subject><subject>Urinary tract. Prostate gland</subject><subject>Uropathogenic Escherichia coli - drug effects</subject><subject>Uropathogenic Escherichia coli - isolation & purification</subject><subject>Women</subject><subject>Young Adult</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqF0t9r1TAUB_AiirtOX_wDJAgiCN3yo0lb38budLKBL1cQX0KantrcpU2XpJv3H_LvNOVeJ-zFpxDyyTmcfJNlrwk-Ibhmp1ulT9ubW1qJJ9mKFALnFNfkabbCDPO8LDg7yl6EsMUYCy6q59kRxaKiXPBV9vtsjKYxLhqNwhw0TMvWmrhDrkPzGMCCjtCi2btJxd79hDHRi6B78Eb3RiHtrEGddwPqYFAW0HqOukcJglcWTV7pVB1Qum5gjOEjWu4Mk_ImuHFpE-9dau7vYBfQvYl9AhztQHlkxgj-TtmX2bNO2QCvDutx9u3Txeb8Mr_--vnL-dl1rouijjlrtRI1B4rbslItCEYYSyNXRa0rQQsGVAPGtSYdblQFWjNWlxSaTtW1bjg7zt7v607e3c4QohxMehRr1QhuDrLCJa0wIeK_suSclJSIKsm3j-TWzX5MYyyoIEsSCX3YI-1dCB46OXkzKL-TBMslZZlSlvuUE35zqDg3A7QP9G-sCbw7ABW0sp1Xozbhn2OM4PQtksv3zoQIvx7Olb-RomQll5fff0i83hT06moj1-wP3wrCpA</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>den Heijer, C. D. J.</creator><creator>Donker, G. A.</creator><creator>Maes, J.</creator><creator>Stobberingh, E. E.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval</title><author>den Heijer, C. D. J. ; Donker, G. A. ; Maes, J. ; Stobberingh, E. 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Antiparasitic agents</topic><topic>Antimicrobial agents</topic><topic>antimicrobial resistance</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the urinary system</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>community-acquired</topic><topic>Comparative analysis</topic><topic>cystitis</topic><topic>Drug Prescriptions - standards</topic><topic>Drug Prescriptions - statistics & numerical data</topic><topic>Drug Utilization - statistics & numerical data</topic><topic>E coli</topic><topic>ESBLs</topic><topic>Escherichia coli</topic><topic>Escherichia coli Infections - microbiology</topic><topic>Female</topic><topic>General Practice</topic><topic>Guideline Adherence - statistics & numerical data</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Netherlands</topic><topic>Pathogens</topic><topic>Pharmacology. Drug treatments</topic><topic>Prescriptions</topic><topic>Time Factors</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract diseases</topic><topic>Urinary Tract Infections - microbiology</topic><topic>Urinary tract. Prostate gland</topic><topic>Uropathogenic Escherichia coli - drug effects</topic><topic>Uropathogenic Escherichia coli - isolation & purification</topic><topic>Women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>den Heijer, C. D. J.</creatorcontrib><creatorcontrib>Donker, G. A.</creatorcontrib><creatorcontrib>Maes, J.</creatorcontrib><creatorcontrib>Stobberingh, E. 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D. J.</au><au>Donker, G. A.</au><au>Maes, J.</au><au>Stobberingh, E. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>65</volume><issue>10</issue><spage>2128</spage><epage>2133</epage><pages>2128-2133</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Objectives To optimize empirical treatment of urinary tract infections (UTIs), regular evaluation of the antibiotic susceptibility of the most common uropathogen, Escherichia coli, is necessary. We compared the antibiotic prescription rate for UTIs in women and the E. coli antibiotic susceptibility results, including the prevalence of extended-spectrum β-lactamase (ESBL)-producing strains, in 2009 with data collected 5 years earlier. Patients and methods Urinary samples from female patients with symptoms of uncomplicated UTI in 42 general practices were collected over a 6 month period. Uropathogens were identified and the antibiotic susceptibility of E. coli was determined. Results We analysed 970 urine cultures, of which 785 (81%) were considered positive (≥103 cfu/mL). E. coli accounted for 72% of the isolates. ESBLs showed an increase between the two surveys (0.1% versus 1%; P < 0.001), while no difference in antibiotic susceptibility to the commonly used antimicrobial agents for UTIs was observed. A significantly lower susceptibility rate to co-amoxiclav was observed in the eastern region of the Netherlands, as compared with the northern region (80% versus 92%; P < 0.05). Consistent with national guidelines, the prescription rate of trimethoprim decreased over time (19% versus 5%; P < 0.05) whereas nitrofurantoin and fosfomycin rates showed an increase (58% versus 66% and 0% versus 6% respectively, both P < 0.05). Conclusions Over a 5 year period, the antibiotic susceptibility of uropathogenic E. coli did not change in female patients with uncomplicated UTI in the Netherlands, but ESBL prevalence increased. With respect to the prescription of antimicrobial agents, compliance with national UTI guidelines was good.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>20682565</pmid><doi>10.1093/jac/dkq286</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology antibiotic use Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents antimicrobial resistance Bacterial diseases Bacterial diseases of the urinary system Biological and medical sciences Child community-acquired Comparative analysis cystitis Drug Prescriptions - standards Drug Prescriptions - statistics & numerical data Drug Utilization - statistics & numerical data E coli ESBLs Escherichia coli Escherichia coli Infections - microbiology Female General Practice Guideline Adherence - statistics & numerical data Human bacterial diseases Humans Infectious diseases Medical sciences Microbial Sensitivity Tests Middle Aged Nephrology. Urinary tract diseases Netherlands Pathogens Pharmacology. Drug treatments Prescriptions Time Factors Urinary system involvement in other diseases. Miscellaneous Urinary tract diseases Urinary Tract Infections - microbiology Urinary tract. Prostate gland Uropathogenic Escherichia coli - drug effects Uropathogenic Escherichia coli - isolation & purification Women Young Adult |
| title | Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval |
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