Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations

Previous studies have shown that iron deficiency (ID) increases brain manganese (Mn), but specific regional changes have not been addressed. Weanling rats were fed one of three semipurified diets: control (CN), iron deficient (ID), or iron deficient/manganese fortified (IDMn+). Seven brain regions w...

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Published in:Biological trace element research 2002, Vol.87 (1-3), p.143-156
Main Authors: Erikson, Keith M, Shihabi, Zakariya K, Aschner, Judy L, Aschner, Michael
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - metabolism
Animals
Body Weight
Brain
Brain - metabolism
Central nervous system
Deficiency Diseases - metabolism
Iron
Iron - deficiency
Male
Manganese
Manganese - metabolism
Manganese compounds
Neurochemistry
Nutrient deficiency
Organ Size
Parkinson's disease
Rats
Rats, Sprague-Dawley
Risk factors
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Shihabi, Zakariya K
Aschner, Judy L
Aschner, Michael
description Previous studies have shown that iron deficiency (ID) increases brain manganese (Mn), but specific regional changes have not been addressed. Weanling rats were fed one of three semipurified diets: control (CN), iron deficient (ID), or iron deficient/manganese fortified (IDMn+). Seven brain regions were analyzed for Mn concentration and amino acid (glutamate, glutamine, taurine, gamma-aminobutyric acid) concentrations. Both ID and IDMn+ diets caused significant (p
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Weanling rats were fed one of three semipurified diets: control (CN), iron deficient (ID), or iron deficient/manganese fortified (IDMn+). Seven brain regions were analyzed for Mn concentration and amino acid (glutamate, glutamine, taurine, gamma-aminobutyric acid) concentrations. Both ID and IDMn+ diets caused significant (p&lt;0.05) increases in Mn concentration across brain regions compared to CN. The hippocampus was the only brain region in which the IDMn+ group accumulated significantly more Mn than both the CN and ID groups. ID significantly decreased GABA concentration in hippocampus, caudate putamen, and globus pallidus compared to CN rats. Taurine was significantly increased in the substantia nigra of the IDMn+ group compared to both ID and CN. ID also altered glutamate and glutamine concentrations in cortex, caudate putamen, and thalamus compared to CN. In the substantia nigra, Mn concentration positively correlated with increased taurine concentration, whereas in caudate putamen, Mn concentration negatively correlated with decreased GABA. 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1559-0720
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subjects Amino acids
Amino Acids - metabolism
Animals
Body Weight
Brain
Brain - metabolism
Central nervous system
Deficiency Diseases - metabolism
Iron
Iron - deficiency
Male
Manganese
Manganese - metabolism
Manganese compounds
Neurochemistry
Nutrient deficiency
Organ Size
Parkinson's disease
Rats
Rats, Sprague-Dawley
Risk factors
title Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations
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