Stability of the radiopharmaceutical [ [formula omitted]]DMSA: Study of the ligand exchange reaction with [ 99Tc]EDTA

A kinetic study was made of the ligand exchange reaction between [ 99 m Tc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes—[ 99 m Tc]EDTA and [ 99 m Tc]DMSA—ha...

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Bibliographic Details
Published in:The International journal of applied radiation and isotopes 1983-11, Vol.34 (11), p.1505-1508
Main Authors: Garcia Muñoz, Mc, Garcia Domenech, R., Galvez Alvarez, J., Moreno Frigols, JL
Format: Article
Language:English
Subjects:
Chemistry
Drug Stability
Edetic Acid
Exact sciences and technology
Hydrogen-Ion Concentration
Inorganic chemistry and origins of life
Kinetics and mechanism of reactions
Ligands
Organotechnetium Compounds
Succimer
Sulfhydryl Compounds
Technetium
Technetium Tc 99m Dimercaptosuccinic Acid
Temperature
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Summary:A kinetic study was made of the ligand exchange reaction between [ 99 m Tc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes—[ 99 m Tc]EDTA and [ 99 m Tc]DMSA—have a similar stability. Furthermore, the existence of an acid-basic catalysis for the global exchange reaction was established, and the catalytic parameters were calculated. These data were obtained by radiochromatography and visible spectrophotometry.
ISSN:0020-708X
DOI:10.1016/0020-708X(83)90284-3