Loading…
Lymphosarcoma in the Rabbit: Genetics and Pathology
Lymphosarcoma occurred often in the WH strain of rabbits and had a hereditary basis. Lymphosarcoma appeared in 16 females and 13 males. The inheritance indicated an autosomal recessive gene conferring susceptibility to lymphosarcoma. We designated this gene Is. Our data were compatible with both con...
Saved in:
Published in: | JNCI : Journal of the National Cancer Institute 1970-10, Vol.45 (4), p.719-729 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Lymphosarcoma occurred often in the WH strain of rabbits and had a hereditary basis. Lymphosarcoma appeared in 16 females and 13 males. The inheritance indicated an autosomal recessive gene conferring susceptibility to lymphosarcoma. We designated this gene Is. Our data were compatible with both concepts of genetic susceptibility to lymphosarcoma and vertical transmission of a virus. Affected rabbits usually died between the ages of 5 and 13 months. The neoplastic involvement of lymphoreticular organs and other organs, especially kidneys, corresponded to a pattern observed in lymphosarcoma of other domestic animals. Specifically, it resembled in many ways visceral lymphosarcomatosis of cats which has been proved unequivocally to be caused by feline leukemia virus. This similarity between rabbit and cat lymphosarcomas involved both sites of onset and distribution of the neoplastic lesions and the hematologic findings of a predominantly aleukemic picture. However, in rabbit lymphosarcomas, often a relative increase in lymphoid cells was found which included both immature and atypical forms. Because rabbits are valuable in laboratory investigations, the finding of lymphosarcoma provides a new and important model for oncogenic studies. |
---|---|
ISSN: | 0027-8874 1460-2105 |
DOI: | 10.1093/jnci/45.4.719 |