Bioavailability of Propylthiouracil in Humans

□ Single lots of five commercially available 50-mg propylthiouracil formulations were evaluated in vitro and in vivo. Each product met the USP XIX specifications for drug content, content uniformity, and disintegration time. However, major differences were noted among products in their rate and exte...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1983-12, Vol.72 (12), p.1409-1412
Main Authors: Ringhand, H.P., Ritschel, W.A., Meyer, M.C., Straughn, A.B., Cabana, B.E.
Format: Article
Language:English
Subjects:
bioavailability
Bioavailability-propylthiouracil
Bioavailability—propylthiouracil, human plasma, correlation with in vitro dissolution
Biological and medical sciences
Biological Availability
correlation with in vitro dissolution
correlation with in vivo bioavailability
Dissolution
Dissolution, in vitro—propylthiouracil, correlation with in vivo bioavailability, humans
Hormones. Endocrine system
human plasma
Humans
in vitro-propylthiouracil
Male
Medical sciences
Pharmacology. Drug treatments
Propylthiouracil - metabolism
Propylthiouracil-human plasma levels in vivo
Propylthiouracil—human plasma levels in vivo, bioavailability, correlation with in vitro dissolution
Solubility
Time Factors
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Summary:□ Single lots of five commercially available 50-mg propylthiouracil formulations were evaluated in vitro and in vivo. Each product met the USP XIX specifications for drug content, content uniformity, and disintegration time. However, major differences were noted among products in their rate and extent of dissolution. Statistically significant differences (p
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600721211