Immunocytochemistry and ultrastructure of the neuropil located ventral to the rat supraoptic nucleus

The neuropil located ventral to the SON was investigated by the use of immunoperoxidase staining for neurophysins, oxytocin and vasopressin, and electron microscopy. The study was performed in six groups of rats: 1) control; 2) infusion of isotonic saline into the CSF; 3) infusion of hypertonic sali...

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Bibliographic Details
Published in:Cell and tissue research 1984-01, Vol.236 (1), p.171-180
Main Authors: YULIS, C. R, PERUZZO, B, RODRIGUEZ, E. M
Format: Article
Language:English
Subjects:
Anatomy
Animals
Axons - ultrastructure
Biological and medical sciences
Central nervous system
Dehydration - physiopathology
Dendrites - ultrastructure
Fundamental and applied biological sciences. Psychology
Male
Microscopy, Electron
Neurons - cytology
Neurons - physiology
Neurons - ultrastructure
Neurophysins - analysis
Rats
Sodium Chloride - pharmacology
Supraoptic Nucleus - cytology
Supraoptic Nucleus - physiology
Supraoptic Nucleus - ultrastructure
Vertebrates: nervous system and sense organs
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Summary:The neuropil located ventral to the SON was investigated by the use of immunoperoxidase staining for neurophysins, oxytocin and vasopressin, and electron microscopy. The study was performed in six groups of rats: 1) control; 2) infusion of isotonic saline into the CSF; 3) infusion of hypertonic saline into the CSF; 4) drinking hypertonic saline for 4 days; 5) same as group 4 but injection of colchicine into the CSF on second day of dehydration; 6) salt loading for 3 months. In the control rats the ventral neuropil contained a few immunoreactive processes, the general morphology of which was completely different from that of the neurosecretory axons emerging from the SON at its dorsal aspect. In rats of groups 3 to 6 the ventral processes (VP) became loaded with neurosecretory granules, whereas the perikarya and axons were depleted. Based on their general morphology and reactivity pattern it is suggested that the VP are dendrites. Most of these "dendrites" were embedded in a glial cushion formed by the processes of a particular type of marginal glia. Some of these "dendrites" enveloped an arteriole penetrating the optic tract. All VP were rich in synaptic contacts. The possibility that the VP of neurosecretory cells may be functionally related to the subarachnoid CSF and the arteriolar blood flow is discussed.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00216528