Feline Leukemia-Virus Infection of Kittens: Mortality Associated With Atrophy of the Thymus and Lymphoid Depletion

Cats infected neonatally with feline leukemia virus (FeLV) had a higher death rate than their littermate controls. Many showed retarded growth rate and died at 8–12 weeks of age. The major pathological finding was atrophy of the thymus and depletion of other lymphoid tissues; some cats had intercurr...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1971-10, Vol.47 (4), p.807-817
Main Authors: Anderson, Lindsay J., Jarrett, W. F. H., Jarrett, O., Laird, Helen M.
Format: Article
Language:English
Subjects:
Animals
Atrophy
Cats
Leukemia, Experimental - mortality
Leukemia, Experimental - pathology
Leukemia, Lymphoid - pathology
Lymph Nodes - pathology
Lymphoma, Non-Hodgkin - pathology
Lymphopenia
Microscopy, Electron
Retroviridae - pathogenicity
Thymus Gland - pathology
Virus Replication
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Summary:Cats infected neonatally with feline leukemia virus (FeLV) had a higher death rate than their littermate controls. Many showed retarded growth rate and died at 8–12 weeks of age. The major pathological finding was atrophy of the thymus and depletion of other lymphoid tissues; some cats had intercurrent infections. Catsdeveloping lymphoid malignancies as well as atrophy of the thymus died with either alimentary lymphosarcoma or lymphoblastic leukemia. Thesyndrome as found in 29 cats is described.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/47.4.807