Does Primary Biliary Cirrhosis in Men Differ from Primary Biliary Cirrhosis in Women?

Primary biliary cirrhosis is infrequently diagnosed in men, so that the clinical, biochemical and histopathological spectrum of this disease in men has not been evaluated. Therefore, we studied 30 men who had a histological diagnosis of primary biliary cirrhosis and had positive tests for antimitoch...

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Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 1984-07, Vol.4 (4), p.671-677
Main Authors: Rubel, Lawrence R., Rabin, Lionel, Seeff, Leonard B., Licht, Harvey, Cuccherini, Brenda A.
Format: Article
Language:English
Subjects:
Adult
Aged
Autoantibodies - analysis
Bile Ducts - pathology
Bilirubin - blood
Biological and medical sciences
Cholestasis - etiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver - pathology
Liver Cirrhosis, Biliary - complications
Liver Cirrhosis, Biliary - pathology
Liver Cirrhosis, Biliary - physiopathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Mitochondria, Liver - immunology
Other diseases. Semiology
Sex Characteristics
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Summary:Primary biliary cirrhosis is infrequently diagnosed in men, so that the clinical, biochemical and histopathological spectrum of this disease in men has not been evaluated. Therefore, we studied 30 men who had a histological diagnosis of primary biliary cirrhosis and had positive tests for antimitochondrial antibodies. Five patients had no hepatobiliary symptoms, and two of these patients had neither biochemical nor histological evidence of cholestasis. These 30 male patients' findings were compared with the findings in 30 age‐matched women who also had primary biliary cirrhosis and antimitochondrial antibodies. Six of these patients were asymptomatic. Clinical findings and symptomatic status, in addition to biochemical and histopathological features, were generally similar in both male and female patients. The possible significance of higher serum alkaline phosphatase activities and lower frequency of occurrence of piecemeal necrosis in men with primary biliary cirrhosis, as compared with women, requires further study.
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840040418