Effects of long-lasting stimulation of extensor muscle nerves on pulmonary ventilation in cats

Increments in pulmonary ventilation were shown to occur in anaesthetized cats during long-lasting stimulation of a peripherally cut extensor muscle nerve at maximal intensity for group I afferent fibers. However, these increments tended to gradually adapt to a lower value when stimuli were delivered...

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Bibliographic Details
Published in:Pflügers Archiv 1984-04, Vol.400 (4), p.409-412
Main Authors: CARCASSI, A. M, CONCU, A, DECANDIA, M, ONNIS, M, ORANI, G. P, PIRAS, G. B
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Biological and medical sciences
Carbon Dioxide
Cardiorespiratory control. Arterial mecano- and chemoreceptor
Cats
Electric Stimulation
Fundamental and applied biological sciences. Psychology
Hindlimb
Muscles - innervation
Partial Pressure
Respiration
Space life sciences
Tidal Volume
Time Factors
Vertebrates: respiratory system
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Summary:Increments in pulmonary ventilation were shown to occur in anaesthetized cats during long-lasting stimulation of a peripherally cut extensor muscle nerve at maximal intensity for group I afferent fibers. However, these increments tended to gradually adapt to a lower value when stimuli were delivered at high frequency and constant rate whereas a tendency to potentiation, up to a steady state, occurred when stimulation was intermittent. End-tidal PCO2 initially decreased with a tendency to adaptation in the case of continuous stimulation, and decreased progressively in the case of intermittent stimulation. It is concluded that the nervous mechanisms producing hyperpnoea exhibit fatigue during their constant excitation while their effects sum up during intermittent stimulation.
ISSN:0031-6768
1432-2013
DOI:10.1007/BF00587541