Marrow changes in paraplegic patients

Immobilization leads to a rapid bone loss resulting from both an increased bone resorption, and a decreased bone formation. In complete paralysis following spinal cord injury, 33% of the iliac trabecular bone is lost over 6 months, before a new steady state without further loss is reached. The excre...

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Bibliographic Details
Published in:Calcified tissue international 1984-12, Vol.36 (3), p.338-340
Main Authors: MINAIRE, P, EDOUARD, C, ARLOT, M, MEUNIER, P. J
Format: Article
Language:English
Subjects:
Adipose Tissue - pathology
Adolescent
Adult
Biological and medical sciences
Bone and Bones - diagnostic imaging
Bone Marrow - pathology
Bone Resorption
Humans
Immobilization
Injuries of the nervous system and the skull. Diseases due to physical agents
Medical sciences
Middle Aged
Paraplegia - etiology
Paraplegia - pathology
Space life sciences
Spinal Cord Injuries - complications
Time Factors
Tomography, X-Ray Computed
Traumas. Diseases due to physical agents
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Summary:Immobilization leads to a rapid bone loss resulting from both an increased bone resorption, and a decreased bone formation. In complete paralysis following spinal cord injury, 33% of the iliac trabecular bone is lost over 6 months, before a new steady state without further loss is reached. The excretion of calcium and hydroxyproline declines over this same period from initial high values to reach stable, but elevated levels. In normal trabecular bone, marrow varies between 75 to 85% of the total volume, and only 25% is yellow, adipose marrow. This report details the marrow changes after spinal cord injury in a larger series of patients some of whom had serial biopsies.
ISSN:0171-967X
1432-0827
DOI:10.1007/BF02405340