Mandibular osteosclerotic lesion of a parotid salivary duct carcinoma: Demonstration of the neural tropism of these tumors

Summary Introduction Salivary duct carcinoma (SDC) is an uncommon entity of salivary gland cancers with a poor prognosis due to local aggressiveness or distant recurrences involving lymph nodes, lung, and long bones, in which secondary lesions are usually osteolytic. The authors report the first cas...

Full description

Saved in:
Bibliographic Details
Published in:European annals of otorhinolaryngology, head and neck diseases head and neck diseases, 2010-11, Vol.127 (5), p.189-192
Main Authors: Lazard, D.-S, Baglin, A.-C, Baujat, B, Cox, A, Condette-Auliac, S, Chabolle, F
Format: Article
Language:English
Subjects:
Carcinoma - complications
Carcinoma - pathology
Cranial Nerve Neoplasms - complications
Facial Nerve Diseases - complications
Female
Free flap
Head and neck cancer
HER-2/ neu
Humans
Mandibular Diseases - etiology
Metastasis
Middle Aged
Neoplasm Invasiveness
Osteosclerosis - etiology
Otolaryngology
p53
Parotid
Parotid Neoplasms - complications
Parotid Neoplasms - pathology
Tropism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Introduction Salivary duct carcinoma (SDC) is an uncommon entity of salivary gland cancers with a poor prognosis due to local aggressiveness or distant recurrences involving lymph nodes, lung, and long bones, in which secondary lesions are usually osteolytic. The authors report the first case of mandibular SDC, atypical due to its osteosclerotic presentation and its site, attributed to aggressive neural spread of the tumor along the trigeminal nerve. Case study This asymptomatic osteosclerotic bone involvement was diagnosed based on pathological enhancement of the trigeminal nerve demonstrated on MRI and was accompanied by facial nerve involvement up to its third intracranial portion. Radical surgery ensured disease control with continued good quality of life at the 4-year follow-up visit. Conclusion Nerve enhancement on MRI and determination of specific tumor markers (HER-2/ neu and p53) should be taken into account to evaluate the prognosis of SDC and to propose appropriate surgical treatment.
ISSN:1879-7296
1879-730X
DOI:10.1016/j.anorl.2010.07.007