Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors

Six family transcription factors play important roles in craniofacial development. Their transcriptional activity can be modified by cofactor proteins. Two Six genes and one cofactor gene (Eya1) are involved in the human Branchio‐otic (BO) and Branchio‐otic‐renal (BOR) syndromes. However, mutations...

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Bibliographic Details
Published in:Developmental dynamics 2010-12, Vol.239 (12), p.3446-3466
Main Authors: Neilson, Karen M., Pignoni, Francesca, Yan, Bo, Moody, Sally A.
Format: Article
Language:English
Subjects:
Animals
Branchio‐otic syndrome
Branchio‐otic‐renal syndrome
Co-Repressor Proteins - genetics
Co-Repressor Proteins - metabolism
Computational Biology
craniofacial development
Embryo, Nonmammalian - metabolism
Eya
Gadd45
Gene Expression Regulation, Developmental
Groucho
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
In Situ Hybridization
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
neural crest
Neural Crest - embryology
placodes
sine oculis
Six1
Six2
Sobp
Transcription Factors - genetics
Transcription Factors - metabolism
Xenopus laevis - embryology
Xenopus Proteins - genetics
Xenopus Proteins - metabolism
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Summary:Six family transcription factors play important roles in craniofacial development. Their transcriptional activity can be modified by cofactor proteins. Two Six genes and one cofactor gene (Eya1) are involved in the human Branchio‐otic (BO) and Branchio‐otic‐renal (BOR) syndromes. However, mutations in Six and Eya genes only account for approximately half of these patients. To discover potential new causative genes, we searched the Xenopus genome for orthologues of Drosophila cofactor proteins that interact with the fly Six‐related factor, SO. We identified 33 Xenopus genes with high sequence identity to 20 of the 25 fly SO‐interacting proteins. We provide the developmental expression patterns of the Xenopus orthologues for 11 of the fly genes, and demonstrate that all are expressed in developing craniofacial tissues with at least partial overlap with Six1/Six2. We speculate that these genes may function as Six‐interacting partners with important roles in vertebrate craniofacial development and perhaps congenital syndromes. Developmental Dynamics 239:3446–3466, 2010. © 2010 Wiley‐Liss, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.22484