Recurrent Non-melanoma Skin Cancer: Remission of Field Cancerization after Conversion from Calcineurin Inhibitor- to Proliferation Signal Inhibitor-based Immunosuppression in a Cardiac Transplant Recipient

Abstract Non-melanoma skin cancers (NMSCs) are the most common malignancies after solid organ transplantation. Their incidence increases with time after transplantation. Calcineurin-inhibitors (CNIs) and azathioprine are known as skin neoplasia-initiating and -enhancing immunosuppressants. In contra...

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Bibliographic Details
Published in:Transplantation proceedings 2010-11, Vol.42 (9), p.3871-3875
Main Authors: Signorell, J, Hunziker, T, Martinelli, M, Koestner, S.C, Mohacsi, P.J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Calcineurin Inhibitors
Carcinoma, Squamous Cell - enzymology
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Cell Proliferation - drug effects
Drug Therapy, Combination
Everolimus
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Heart Transplantation - adverse effects
Humans
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Male
Medical sciences
Middle Aged
Neoplasm Recurrence, Local
Photochemotherapy
Signal Transduction - drug effects
Sirolimus - analogs & derivatives
Sirolimus - therapeutic use
Skin Neoplasms - enzymology
Skin Neoplasms - etiology
Skin Neoplasms - pathology
Skin Neoplasms - therapy
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tacrolimus - adverse effects
Time Factors
Tissue, organ and graft immunology
TOR Serine-Threonine Kinases - antagonists & inhibitors
Transplantation, Homologous
Treatment Outcome
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Description
Summary:Abstract Non-melanoma skin cancers (NMSCs) are the most common malignancies after solid organ transplantation. Their incidence increases with time after transplantation. Calcineurin-inhibitors (CNIs) and azathioprine are known as skin neoplasia-initiating and -enhancing immunosuppressants. In contrast, increasing clinical experience suggests a relevant antiproliferative effect of mammalian target of rapamycin inhibitors, also named proliferation signal inhibitors (PSIs). We report the case of a cardiac allograft recipient with an impressive and consolidated reduction of recurrent NMSC, observed after conversion from CNI-therapy to a PSI-based protocol.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2010.07.090