Effects of Moisture in Compaction of Particulate Material

• Published in: Journal of pharmaceutical sciences 1971-11, Vol.60 (11), p.1704-1708
• Main Authors: Rees, John E., Shotton, Edward
• Format: Article
• Language: English
• Subjects: Compaction process-role of moisture; Compaction process—role of moisture, ideal particulate system; Compression changes-lubricant efficiency assessment; Compression changes—lubricant efficiency assessment, ideal particulate system; decahydronaphthalene; Die wall effects-studied using ideal particulate system of sodium chloride and water; Die wall effects—studied using ideal particulate system of sodium chloride and water, decahydronaphthalene, or paraffin; Drug Compounding; Humidity; ideal particulate system; Naphthalenes; or paraffin; Paraffin; Powders; Pressure; role in compaction process; Sodium Chloride; Tablets; Water; Water as lubricant-with sodium chloride; Water as lubricant—with sodium chloride, role in compaction process
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600601127

By using an ideal particulate system of crystalline sodium chloride and three liquids—water, decahydronaphthalene, and light liquid paraffin—the role of moisture in the compaction process was investigated. Interrelated effects of liquid at the die wall boundary and within the compact are discussed. Although differences in the behavior of the three liquids could be attributed partly to the viscosity difference, water apparently exerted a boundary lubricant effect in addition to hydrodynamic properties. Despite its lower viscosity, water was, therefore, a more effective lubricant than light liquid paraffin. In general decahydronaphthalene adversely affected the compaction process. Cumulative changes in the difference between applied and transmitted force during consecutive compressions can be used to assess the lubricant efficiency of materials.