Expression of Sox 9 and type II and X collagens in regenerated condyle

The present study was designed to examine the expression of Sox 9 and type II and X collagens in regenerated condyle resulting from the use of a functional appliance. Ninety, 3-week-old, mice were divided equally into the following groups: two experimental groups (condylectomy group and condylectomy...

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Bibliographic Details
Published in:European journal of orthodontics 2010-12, Vol.32 (6), p.677-680
Main Authors: Fujita, Tadashi, Nakano, Mao, Ohtani, Junji, Kawata, Toshitsugu, Kaku, Masato, Motokawa, Masahide, Tsuka, Natsumi, Hayashi, Hidetaka, Tanne, Kazuo
Format: Article
Language:English
Subjects:
Animals
Chondrogenesis - genetics
Collagen Type II - biosynthesis
Collagen Type II - genetics
Collagen Type X - biosynthesis
Collagen Type X - genetics
Dentistry
Gene Expression
Mandibular Advancement - instrumentation
Mandibular Condyle - surgery
Mice
Mice, Inbred C57BL
Models, Animal
Occlusal Splints
Orthodontic Appliances, Functional
Osteogenesis - genetics
Regeneration - genetics
SOX9 Transcription Factor - biosynthesis
SOX9 Transcription Factor - genetics
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Summary:The present study was designed to examine the expression of Sox 9 and type II and X collagens in regenerated condyle resulting from the use of a functional appliance. Ninety, 3-week-old, mice were divided equally into the following groups: two experimental groups (condylectomy group and condylectomy with functional appliance group) and the corresponding control group. In the condylectomy group, a unilateral condylectomy was performed on the right side. In the condylectomy with appliance group, the mandible was repositioned in a forward direction using a functional appliance after unilateral condylectomy. The expression of Sox 9 and type II and X collagens in the condyle was determined immunohistochemically 4 weeks after surgery. In mice with a condylectomy, the expression was minimal. On the other hand, these factors were highly expressed in the condylectomized side with the appliance. It is thus speculated that cartilaginous regeneration is due to the expression of chondrogenic factors, such as Sox 9 and type II and X collagens. It is also suggested that condyle regeneration results from an optimal intra-articular environment with appropriate joint spaces achieved by condylar repositioning.
ISSN:0141-5387
1460-2210
DOI:10.1093/ejo/cjp163