Characterization and Genetics of Hæmoglobin G

IN the course of a survey of Gold Coast Africans 1 , one individual was discovered who had both normal hæmoglobin and one hitherto not known which was designated as hæmoglobin G 2 . Hæmoglobin G was found to differ from all other known hæmoglobins in its mobility on paper electrophoresis at p H 8.6...

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Bibliographic Details
Published in:Nature (London) 1955-05, Vol.175 (4463), p.850-851
Main Authors: EDINGTON, G. M, LEHMANN, H, SCHNEIDER, ROSE G
Format: Article
Language:English
Subjects:
Hemoglobins
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
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Summary:IN the course of a survey of Gold Coast Africans 1 , one individual was discovered who had both normal hæmoglobin and one hitherto not known which was designated as hæmoglobin G 2 . Hæmoglobin G was found to differ from all other known hæmoglobins in its mobility on paper electrophoresis at p H 8.6 (veronal buffer). The hæmoglobins most similar in mobility were sickle-cell hæmoglobin ( S ), fœtal hæmoglobin ( F ) and hæmoglobin D . S could in addition be differentiated by its low solubility when in the reduced state, and F by its resistance towards denaturation by alkali. For the distinction from hæmoglobin D , reliance had to be placed on the reported mobility of the latter, which was exactly that of S in open-boundary electrophoresis at acid and at alkaline p H 3 . Further steps have now been taken to establish the properties of hæmoglobin G .
ISSN:0028-0836
1476-4687
DOI:10.1038/175850a0