Aldosterone Production Rates in Manic-Depressive Psychosis

In 1963 Coppen and Shaw reported that patients with manic-depressive psychosis showed, on clinical recovery, a significant decrease in exchangeable sodium, and in residual sodium (exchangeable minus extracellular sodium), presumed intracellular, per litre of body water. Coppen, Shaw, Malleson and Co...

Full description

Saved in:
Bibliographic Details
Published in:British journal of psychiatry 1972-04, Vol.120 (557), p.399-404
Main Authors: Allsopp, M. N. E., Levell, M. J., Stitch, S. R., Hullin, R. P.
Format: Article
Language:English
Subjects:
Aldosterone - biosynthesis
Aldosterone - urine
Bipolar Disorder - metabolism
Bipolar Disorder - urine
Carbon Isotopes
Chromatography, Thin Layer
Extracellular Space
Female
Humans
Middle Aged
Sodium - urine
Tritium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In 1963 Coppen and Shaw reported that patients with manic-depressive psychosis showed, on clinical recovery, a significant decrease in exchangeable sodium, and in residual sodium (exchangeable minus extracellular sodium), presumed intracellular, per litre of body water. Coppen, Shaw, Malleson and Costain (1966) found a similar type of shift in mania but the deviation from normal was, on average, more extreme. Although low and high sodium diets had no effects on the distribution of sodium in manic-depressive psychotics, the administration of spironolactone resulted in a significant reduction of residual sodium (Coppen, 1970). The possible involvement of aldosterone in these changes led Jenner et al. (1967) to examine aldosterone excretion in a 48-hour cycle patient and Murphy, Goodwin and Bunney (1969) to examine groups of manic and depressed patients. Murphy et al. found lower rates of excretion of aldosterone in depression than in mania, but Jenner et al. found the opposite.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.120.557.399