Effect of Interval between Inoculation of Live Smallpox and Yellow-Fever Vaccines on Antigenicity in Man

In the first part of this study, volunteers were initially given smallpox vaccine; yellow-fever vaccine was given to groups of these volunteers simultaneously, and 3, 7, 14, and 28 days later. Part two was essentially the same, except that yellow-fever vaccine was administered initially, and the tim...

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Bibliographic Details
Published in:The Journal of infectious diseases 1972-10, Vol.126 (4), p.362-371
Main Authors: Tauraso, Nicola M., Myers, Martin G., Nau, Ernest V., O'Brien, Thomas C., Spindel, Sidney S., Trimmer, Roy W.
Format: Article
Language:English
Subjects:
Adult
Analysis of variance
Animals
Antibodies
Antibody Formation
Chick Embryo - immunology
Complement Fixation Tests
Hemagglutination Inhibition Tests
Humans
Immunization
Immunization Schedule
Inoculation
Male
Neutralization Tests
Original Articles
Skin Manifestations
Skin Tests
Smallpox
Smallpox - immunology
Smallpox Vaccine
Smallpox vaccines
Time Factors
Vaccination
Viruses
Volunteerism
Yellow Fever - immunology
Yellow fever virus
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Summary:In the first part of this study, volunteers were initially given smallpox vaccine; yellow-fever vaccine was given to groups of these volunteers simultaneously, and 3, 7, 14, and 28 days later. Part two was essentially the same, except that yellow-fever vaccine was administered initially, and the time of smallpox vaccination varied as indicated above. The results showed that the reactogenicity and antigenicity of live smallpox and yellow-fever vaccines were unaffected by the interval between inoculations. The advantages of administering live-virus vaccines, either simultaneously or at different times, were evaluated. It was suggested that the recommendations on immunization with smallpox and yellow-fever vaccines be modified in light of the findings of this study.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/126.4.362