Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates

The ability of fourteen marine invertebrates to utilize [(14)C]mevalonate for the biosynthesis of isoprenoid compounds was investigated. Several of the animals, in particular crustaceans, bivalve molluscs, a coelenterate and a sponge, were unable to synthesize squalene and sterols, whereas gastropod...

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Bibliographic Details
Published in:Biochemical journal 1972-04, Vol.127 (3), p.471-479
Main Authors: Walton, M J, Pennock, J F
Format: Article
Language:English
Subjects:
Alcohols - biosynthesis
Animals
Annelida - metabolism
Carbon Isotopes
Chromatography, Thin Layer
Cnidaria - metabolism
Crustacea - metabolism
Echinodermata - metabolism
Farnesol - biosynthesis
Fatty Alcohols
Invertebrates - metabolism
Marine Biology
Mevalonic Acid - metabolism
Mollusca - metabolism
Porifera - metabolism
Squalene - biosynthesis
Sterols - biosynthesis
Terpenes
Ubiquinone - biosynthesis
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Summary:The ability of fourteen marine invertebrates to utilize [(14)C]mevalonate for the biosynthesis of isoprenoid compounds was investigated. Several of the animals, in particular crustaceans, bivalve molluscs, a coelenterate and a sponge, were unable to synthesize squalene and sterols, whereas gastropod molluscs, echinoderms, an annelid and a sponge could. Regardless of sterol-synthesizing ability the animals (with the exception of a sponge) always made dolichol and ubiquinone, and thus a specific block in squalene and sterol synthesis was indicated in some animals. Radioactivity accumulated in relatively large amounts in farnesol and geranylgeraniol in those animals incapable of making sterols.
ISSN:0264-6021
DOI:10.1042/bj1270471