Sleep pattern in an experimental model of chronic kidney disease

The prevalence of sleep disorders is significantly elevated in chronic kidney disease (CKD) patients. Numerous factors likely contribute to the high prevalence of sleep problems in uremic patients. The objective of this study was to evaluate the long-term sleep pattern changes in uremic rats during...

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Published in:American journal of physiology. Renal physiology 2010-12, Vol.299 (6), p.F1379-F1388
Main Authors: Hirotsu, Camila, Tufik, Sergio, Bergamaschi, Cassia Toledo, Tenorio, Neuli Maria, Araujo, Paula, Andersen, Monica Levy
Format: Article
Language:English
Subjects:
Animal behavior
Animals
Cholesterol
Heart Rate
Hypertension - etiology
Kidney diseases
Kidney Failure, Chronic - complications
Lipids - blood
Male
Rats
Rats, Wistar
Renal Insufficiency, Chronic - complications
Rodents
Sleep Deprivation - etiology
Sleep Deprivation - physiopathology
Sleep Wake Disorders - etiology
Sleep Wake Disorders - physiopathology
Studies
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Summary:The prevalence of sleep disorders is significantly elevated in chronic kidney disease (CKD) patients. Numerous factors likely contribute to the high prevalence of sleep problems in uremic patients. The objective of this study was to evaluate the long-term sleep pattern changes in uremic rats during disease progression. Sleep recordings of the rats were monitored during light and dark periods that lasted 12 h each. These recordings were performed on days 7, 30, 60, and 90 after CKD induction. Cardiovascular, hormonal, and biochemical changes were evaluated at these same time points in control and uremic rats. CKD progression was reflected by the presence of hypertension and progressive increases in urea, creatinine, and cholesterol levels. We also observed hormonal fluctuations of corticosterone and ACTH, which indicated a potential alteration in the hypothalamic-pituitary-adrenal axis in diseased rats. In addition, rats with CKD demonstrated fragmented sleep with a greater number of arousals and decreased sleep efficiency in the light period during disease progression. In the dark period, there was an initial increase in sleep efficiency in CKD rats, but after 90 days of CKD, these animals slept less compared with the control group. Collectively, these metabolic and cardiovascular changes were associated with the persistent alterations in sleep architecture observed in CKD rats.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00118.2010