Malignant lymphoma including Hodgkin's disease occurring in the vicinity of a large medical center (Olmsted County, minn., 1945 through 1969)

• Published in: Cancer 1973-02, Vol.31 (2), p.295-302
• Main Authors: Nobrega, Fred T., Kyle, Robert A., Harrison, Edgar G.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Child; Child, Preschool; Ethnic Groups; Female; Hodgkin Disease - epidemiology; Hodgkin Disease - mortality; Humans; Infant; Lymphoma, Large B-Cell, Diffuse - epidemiology; Lymphoma, Large B-Cell, Diffuse - mortality; Lymphoma, Non-Hodgkin - epidemiology; Lymphoma, Non-Hodgkin - mortality; Male; Middle Aged; Minnesota; Rural Population; Urban Population
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/1097-0142(197302)31:2<295::AID-CNCR2820310205>3.0.CO;2-#

From the medical records of the Mayo Clinic and other institutions providing medical care to local citizens, 167 cases of malignant lymphoma were identified and 164 were confirmed by tissue examination. The average annual incidence rates for all types of nodal lymphoma in Olmsted County showed no significant change for the 25 years of study; there also was no change for all types of extranodal lymphoma. Adjusted incidence rates for nodal cases were 2.4/100,000 for Hodgkin's disease, 4.7/100,000 for lymphosarcoma of various types, and 1.9/100,000 for reticulum cell sarcoma. The combined rates for Hodgkin's disease and lymphosarcoma including the reticulum cell type were higher for urban than for rural Olmsted County, even when adjusted for age. Survivorship studies revealed that Hodgkin's disease carries a somewhat better prognosis than lymphosarcoma types overall while that for reticulum cell sarcoma is significantly poorer.