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Nitroglycerin Sublingual Tablets I: Stability of Conventional Tablets
Nitroglycerin in molded sublingual tablets volatilizes and undergoes intertablet migration. Consequently, tablets that are uniform when manufactured develop enough intertablet dose variation that they frequently fail the USP XVIII content uniformity test. Factors influencing volatilization and migra...
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| Published in: | Journal of pharmaceutical sciences 1973-01, Vol.62 (1), p.122-129 |
|---|---|
| Main Author: | |
| Format: | Article |
| Language: | English |
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| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
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| cited_by | cdi_FETCH-LOGICAL-c3425-90dc958b8d459cf3ea91b9931c653f8095007535bebd39fb6e9e83191285008f3 |
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| cites | cdi_FETCH-LOGICAL-c3425-90dc958b8d459cf3ea91b9931c653f8095007535bebd39fb6e9e83191285008f3 |
| container_end_page | 129 |
| container_issue | 1 |
| container_start_page | 122 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 62 |
| creator | Fusari, Salvatore A. |
| description | Nitroglycerin in molded sublingual tablets volatilizes and undergoes intertablet migration. Consequently, tablets that are uniform when manufactured develop enough intertablet dose variation that they frequently fail the USP XVIII content uniformity test. Factors influencing volatilization and migration are discussed. |
| doi_str_mv | 10.1002/jps.2600620125 |
| format | article |
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Consequently, tablets that are uniform when manufactured develop enough intertablet dose variation that they frequently fail the USP XVIII content uniformity test. Factors influencing volatilization and migration are discussed.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600620125</identifier><identifier>PMID: 4630198</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>and intertablet migration ; Autoanalysis ; Content uniformity ; Content uniformity, nitroglycerin tablets—volatilization and intertablet migration ; Drug Packaging ; Drug Stability ; Drug Storage ; Mouth Floor ; Nitroglycerin - analysis ; Nitroglycerin tablets-stability ; nitroglycerin tablets-volatilization and intertablet migration ; Nitroglycerin tablets—stability, volatilization, and intertablet migration ; nitroglycerin-stability ; Placebos ; Tablets ; Tablets - analysis ; Tablets, nitroglycerin—stability, volatilization, and intertablet migration ; Temperature ; Time Factors ; volatilization</subject><ispartof>Journal of pharmaceutical sciences, 1973-01, Vol.62 (1), p.122-129</ispartof><rights>1973 Wiley‐Liss, Inc., A Wiley Company</rights><rights>Copyright © 1973 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3425-90dc958b8d459cf3ea91b9931c653f8095007535bebd39fb6e9e83191285008f3</citedby><cites>FETCH-LOGICAL-c3425-90dc958b8d459cf3ea91b9931c653f8095007535bebd39fb6e9e83191285008f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600620125$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600620125$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4630198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fusari, Salvatore A.</creatorcontrib><title>Nitroglycerin Sublingual Tablets I: Stability of Conventional Tablets</title><title>Journal of pharmaceutical sciences</title><addtitle>J. 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| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1973-01, Vol.62 (1), p.122-129 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81810650 |
| source | Wiley Online Library (Online service) |
| subjects | and intertablet migration Autoanalysis Content uniformity Content uniformity, nitroglycerin tablets—volatilization and intertablet migration Drug Packaging Drug Stability Drug Storage Mouth Floor Nitroglycerin - analysis Nitroglycerin tablets-stability nitroglycerin tablets-volatilization and intertablet migration Nitroglycerin tablets—stability, volatilization, and intertablet migration nitroglycerin-stability Placebos Tablets Tablets - analysis Tablets, nitroglycerin—stability, volatilization, and intertablet migration Temperature Time Factors volatilization |
| title | Nitroglycerin Sublingual Tablets I: Stability of Conventional Tablets |
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