The Infectivity of the Nucleic Acid of Aerosol-inactivated Poliovirus

Laboratory of Microbiology State University, Catharijnesingel 59 Utrecht, the Netherlands Poliovirus is inactivated rapidly in aerosols at low to moderate relative humidity (r.h.) (Hemmes, Winkler & Kool, 1960; Harper, 1961) and it is of biological and epidemiological importance to know whether...

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Bibliographic Details
Published in:Journal of general virology 1973-01, Vol.18 (1), p.83-86
Main Authors: de Jong, J. C, Harmsen, M, Trouwborst, T
Format: Article
Language:English
Subjects:
Aerosols
Air Microbiology
Carcinoma
Cell Line
Culture Media
Fluoresceins
Humans
Humidity
Laryngeal Neoplasms
Poliovirus - growth & development
Poliovirus - isolation & purification
RNA, Viral - isolation & purification
RNA, Viral - pharmacology
Viral Plaque Assay
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Summary:Laboratory of Microbiology State University, Catharijnesingel 59 Utrecht, the Netherlands Poliovirus is inactivated rapidly in aerosols at low to moderate relative humidity (r.h.) (Hemmes, Winkler & Kool, 1960; Harper, 1961) and it is of biological and epidemiological importance to know whether the nucleic acid remains infective during this process. De Jong & Winkler (1968) have already reported that whole virus and virus RNA are inactivated in parallel. However, during similar studies with the virus of encephalomyocarditis of mice (EMC-virus) it was found that the RNA was not inactivated in aerosols even when the infectivity of the whole virus decreased rapidly (de Jong, 1969). This difference is remarkable because of the resemblance between these viruses in structure and aerosol survival. Moreover, Dubovi (1971) showed that for the structurally related bacteriophage MS2 the infectivity of the RNA, but not the intact virus, was stable in aerosols. We have reinvestigated this problem for poliovirus. Received 17 July 1972; accepted 3 October 1972.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-18-1-83