Safety and antigenicity of temperature sensitive (TS) mutant respiratory syncytial virus (RSV) in infants and children

In attempts to stimulate local respiratory tract immunity to respiratory syncytial virus (RSV), a temperature-sensitive mutant of RSV strain A2 (ts-1 mutant) was administered to 32 infants and children. Evidence of infection was demonstrated in all and no illness accompanied infection in children wh...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1973-07, Vol.52 (1), p.56-63
Main Authors: Kim, H W, Arrobio, J O, Brandt, C D, Wright, P, Hodes, D, Chanock, R M, Parrott, R H
Format: Article
Language:English
Subjects:
Administration, Intranasal
Antibodies, Viral - analysis
Body Fluids - immunology
Child
Child, Preschool
Humans
Infant
Mutation
Nasal Mucosa - secretion
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - microbiology
Orthomyxoviridae Infections - prevention & control
Otitis Media - etiology
Pharynx - microbiology
Respiratory Syncytial Viruses - immunology
Respiratory Syncytial Viruses - isolation & purification
Respiratory Tract Infections - immunology
Respiratory Tract Infections - microbiology
Respiratory Tract Infections - prevention & control
Rhinitis - etiology
Temperature
Vaccination
Vaccines, Attenuated - adverse effects
Viral Vaccines
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Summary:In attempts to stimulate local respiratory tract immunity to respiratory syncytial virus (RSV), a temperature-sensitive mutant of RSV strain A2 (ts-1 mutant) was administered to 32 infants and children. Evidence of infection was demonstrated in all and no illness accompanied infection in children who had prior experience with RSV. Mild rhinitis occurred in seven infants without prior RSV experience and otitis occurred in one of these individuals. Also, genetically altered virus was recovered from some children but this type of virus represented less than 0.1% of virus recovered from the respiratory tract. An ideal RSV mutant would infect without undergoing such reversion or other genetic change and without producing clinical findings such as otitis which would not be acceptable for a vaccine designed for widespread use.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.52.1.56