Human Embryonic Kidneys in Organ Culture: Abnormalities of Development Induced by Decreased Potassium

Human embryonic kidneys of 5 to 12 weeks of gestation were grown in organ culture. Potassium concentrations of 3 to 6 milliequivalents per liter produced decreased ureteral bud branching, failure of nephron induction, and occasional cystic dilatations of the ureteral bud. Normal development of the k...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1973-09, Vol.181 (4105), p.1178-1179
Main Author: Crocker, J F
Format: Article
Language:English
Subjects:
Congenital Abnormalities - etiology
Culture Media
Embryos
Gestational Age
Humans
Hypokalemia
Hypokalemia - complications
Kidney - abnormalities
Kidney - embryology
Kidney - metabolism
Kidneys
Nephrons
Organ Culture Techniques
Oxygen
Polycystic kidney diseases
Potassium
Potassium - metabolism
Pregnancy
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Summary:Human embryonic kidneys of 5 to 12 weeks of gestation were grown in organ culture. Potassium concentrations of 3 to 6 milliequivalents per liter produced decreased ureteral bud branching, failure of nephron induction, and occasional cystic dilatations of the ureteral bud. Normal development of the kidney occurred at potassium concentrations of 6.5 to 10 milliequivalents per liter. These studies confirm the importance of relative stability of the potassium concentration in the development of the embryonic kidney.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.181.4105.1178