Excretion of Yttrium and Lanthanum Chelates of Cyclohexane 1,2- Trans Diamine Tetraacetic Acid and Diethylenetriamine Pentaacetic Acid in Man

THE removal of stable or radioactive toxic elements from the human body is of considerable interest 1 . The modification of tissue distribution and excretion of metal ions by chelating agents has been studied in man and animals in several laboratories 2 . Although ethylenediamine tetraacetic acid ha...

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Bibliographic Details
Published in:Nature (London) 1957-11, Vol.180 (4592), p.919-920
Main Authors: KROLL, HARRY, KORMAN, SAMUEL, SIEGEL, ELSIE, HART, HIRAM E, ROSOFF, BETTY, SPENCER, HERTA, LASZLO, DANIEL
Format: Article
Language:English
Subjects:
Chelating Agents - pharmacology
Cyclohexanes
Diamines
Elements
Humanities and Social Sciences
Lanthanum
letter
multidisciplinary
Old Medline
Pentetic Acid
Polyamines
Science
Science (multidisciplinary)
Yttrium
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Summary:THE removal of stable or radioactive toxic elements from the human body is of considerable interest 1 . The modification of tissue distribution and excretion of metal ions by chelating agents has been studied in man and animals in several laboratories 2 . Although ethylenediamine tetraacetic acid has been the most effective chelating agent thus far studied, it has the disadvantage that relatively large doses are required in order to effect a significant removal of heavy metal ions, particularly radioactive rare earths. Therefore metal chelates having stability constants higher than the corresponding metal chelates of ethylenediamine tetraacetic acid were investigated for their effectiveness in removal of rare earth elements.
ISSN:0028-0836
1476-4687
DOI:10.1038/180919b0