Carboxyhemoglobin exchange between donors and recipients of blood transfusions

The potential toxicity of carbon monoxide in transfused blood has received relatively little attention. Ayres et al.1 demonstrated that a rise in carboxyhemoglobin (COHb) percent saturation from approximately 1% to 5% to 10% causes a notable decrease in the arterial and mixed venous blood oxygen ten...

Full description

Saved in:
Bibliographic Details
Published in:Pediatrics (Evanston) 1973-11, Vol.52 (5), p.716-718
Main Authors: Kandall, S R, Landaw, S A, Thaler, M M
Format: Article
Language:English
Subjects:
Birth Weight
Blood Donors
Blood Gas Analysis
Carbon Monoxide - blood
Carbon Monoxide - metabolism
Carboxyhemoglobin
Chromatography, Gas
Exchange Transfusion, Whole Blood - adverse effects
Female
Hemoglobins
Humans
Hyperbilirubinemia - therapy
Hyperbilirubinemia, Hereditary - therapy
Hypoxia - etiology
Infant Mortality
Infant, Newborn
Infant, Newborn, Diseases - therapy
Pregnancy
Smoking - complications
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The potential toxicity of carbon monoxide in transfused blood has received relatively little attention. Ayres et al.1 demonstrated that a rise in carboxyhemoglobin (COHb) percent saturation from approximately 1% to 5% to 10% causes a notable decrease in the arterial and mixed venous blood oxygen tension in normal adults. Engel et al.2 noted that COHb in newborn infants with hemolytic disease could be altered with exchange blood transfusions. When respiratory distress occurs in such infants, high COHb in transfused blood may, therefore, reduce tissue oxygenation to dangerously low levels. The relationship between COHb in donor blood and in recipients of exchange blood transfusions was examined in 15 infants with neonatal hyperbilirubinemia not associated with pulmonary deficiency.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.52.5.716