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Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma
Summary Background The present study aimed to illustrate differences in characteristics and perception of dyspnea between young atopic adults who have no history of asthma ( never -asthmatics) with or without asymptomatic airway hyperresponsiveness (AHR) and those who had childhood asthma and consid...
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| Published in: | Respiratory medicine 2011-01, Vol.105 (1), p.24-30 |
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| creator | Yoshikawa, Takahiro Kanazawa, Hiroshi |
| description | Summary Background The present study aimed to illustrate differences in characteristics and perception of dyspnea between young atopic adults who have no history of asthma ( never -asthmatics) with or without asymptomatic airway hyperresponsiveness (AHR) and those who had childhood asthma and consider themselves to be grown out of the disease ( past -asthmatics). Methods Blood parameters, lung function and methacholine PC20 were measured in 88 never -asthmatics and 24 past -asthmatics. A perception score of dyspnea at 20% fall in FEV1 (PS20 ) was obtained by interpolation of the two last points on the perception (modified Borg scale)/fall in FEV1 curve during methacholine challenge. Results Thirty-one of 88 never -asthmatics and eighteen of 24 past -asthmatics exhibited AHR (PC20 was |
| doi_str_mv | 10.1016/j.rmed.2010.07.015 |
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Methods Blood parameters, lung function and methacholine PC20 were measured in 88 never -asthmatics and 24 past -asthmatics. A perception score of dyspnea at 20% fall in FEV1 (PS20 ) was obtained by interpolation of the two last points on the perception (modified Borg scale)/fall in FEV1 curve during methacholine challenge. Results Thirty-one of 88 never -asthmatics and eighteen of 24 past -asthmatics exhibited AHR (PC20 was <8 mg/ml). Higher levels of specific IgE to house dust mite in past -asthmatics were observed than never -asthmatics with and without AHR. Mean values of FEV1 and FEF25–75 (%predicted) were significantly lower in past -asthmatics than never -asthmatics without AHR, and the values in never -asthmatics with AHR were intermediate between never -asthmatics without AHR and past -asthmatics. PC20 was not significantly different between past -asthmatics and never -asthmatics with AHR. Of particular interest was that PS20 was significantly lower in never -asthmatics with AHR compared with past -asthmatics. Conclusion The present findings suggest the possibilities that presence or absence of past history of outgrow of childhood asthma might be associated with airway narrowing, sensitization to house dust mite and perception of dyspnea in young asymptomatic adults with atopy and AHR.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2010.07.015</identifier><identifier>PMID: 20708396</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adolescent ; Airway narrowing ; Animals ; Asthma - genetics ; Asthma - immunology ; Asthma - physiopathology ; Asymptomatic airway hyperresponsiveness (AHR) ; Biological and medical sciences ; Bronchial asthma ; Chronic obstructive pulmonary disease, asthma ; Clinical remission ; Dyspnea - etiology ; Dyspnea - physiopathology ; Female ; Forced Expiratory Volume - physiology ; House dust mites ; Humans ; Immunoglobulin E - immunology ; Male ; Medical sciences ; Perception of dyspnea ; Phenotype ; Pneumology ; Pulmonary/Respiratory ; Pyroglyphidae - immunology ; Remission, Spontaneous ; Respiratory Hypersensitivity - genetics ; Respiratory Hypersensitivity - immunology ; Respiratory Hypersensitivity - physiopathology ; Respiratory system : syndromes and miscellaneous diseases ; Spirometry ; Young Adult</subject><ispartof>Respiratory medicine, 2011-01, Vol.105 (1), p.24-30</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-38e7c697101bca2bc11fb5550b06aa80de1a6a3ba3cdabf4bbf63a4348e8abcc3</citedby><cites>FETCH-LOGICAL-c578t-38e7c697101bca2bc11fb5550b06aa80de1a6a3ba3cdabf4bbf63a4348e8abcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23725221$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20708396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshikawa, Takahiro</creatorcontrib><creatorcontrib>Kanazawa, Hiroshi</creatorcontrib><title>Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Summary Background The present study aimed to illustrate differences in characteristics and perception of dyspnea between young atopic adults who have no history of asthma ( never -asthmatics) with or without asymptomatic airway hyperresponsiveness (AHR) and those who had childhood asthma and consider themselves to be grown out of the disease ( past -asthmatics). Methods Blood parameters, lung function and methacholine PC20 were measured in 88 never -asthmatics and 24 past -asthmatics. A perception score of dyspnea at 20% fall in FEV1 (PS20 ) was obtained by interpolation of the two last points on the perception (modified Borg scale)/fall in FEV1 curve during methacholine challenge. Results Thirty-one of 88 never -asthmatics and eighteen of 24 past -asthmatics exhibited AHR (PC20 was <8 mg/ml). Higher levels of specific IgE to house dust mite in past -asthmatics were observed than never -asthmatics with and without AHR. Mean values of FEV1 and FEF25–75 (%predicted) were significantly lower in past -asthmatics than never -asthmatics without AHR, and the values in never -asthmatics with AHR were intermediate between never -asthmatics without AHR and past -asthmatics. PC20 was not significantly different between past -asthmatics and never -asthmatics with AHR. Of particular interest was that PS20 was significantly lower in never -asthmatics with AHR compared with past -asthmatics. Conclusion The present findings suggest the possibilities that presence or absence of past history of outgrow of childhood asthma might be associated with airway narrowing, sensitization to house dust mite and perception of dyspnea in young asymptomatic adults with atopy and AHR.</description><subject>Adolescent</subject><subject>Airway narrowing</subject><subject>Animals</subject><subject>Asthma - genetics</subject><subject>Asthma - immunology</subject><subject>Asthma - physiopathology</subject><subject>Asymptomatic airway hyperresponsiveness (AHR)</subject><subject>Biological and medical sciences</subject><subject>Bronchial asthma</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Clinical remission</subject><subject>Dyspnea - etiology</subject><subject>Dyspnea - physiopathology</subject><subject>Female</subject><subject>Forced Expiratory Volume - physiology</subject><subject>House dust mites</subject><subject>Humans</subject><subject>Immunoglobulin E - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Perception of dyspnea</subject><subject>Phenotype</subject><subject>Pneumology</subject><subject>Pulmonary/Respiratory</subject><subject>Pyroglyphidae - immunology</subject><subject>Remission, Spontaneous</subject><subject>Respiratory Hypersensitivity - genetics</subject><subject>Respiratory Hypersensitivity - immunology</subject><subject>Respiratory Hypersensitivity - physiopathology</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Spirometry</subject><subject>Young Adult</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kl-L1DAUxYMo7uzqF_BBCiI-dcyfJm1BFmRxVVhQUF8NN-ktk7FNatLZpd_elJllYR98CiS_c3PuuZeQV4xuGWXq_X4bR-y2nOYLWm8pk0_IhknBS0FV9ZRsaCurUjHGzsh5SntKaVtV9Dk547SmjWjVhvz-vkMf5mVytuhc32NEbzEVBuc7RF9AWsZpDiPMGQAX72ApdsuEMWKagk_uFj2mVIDvioijS8kFX4Q-C-fdCC_Isx6GhC9P5wX5df3p59WX8ubb569XH29KK-tmLkWDtVVtndsyFrixjPVGSkkNVQAN7ZCBAmFA2A5MXxnTKwGVqBpswFgrLsi7Y90phr8HTLPOViwOA3gMh6QbzmQrFasz-eYRuQ-H6LM5zaiQTAjGq0zxI2VjSClir6foRohLhvQavt7rNXy9hq9prXP4WfT6VPpg1rd7yX3aGXh7AiBZGPoI3rr0wImaS85Z5j4cOcyR3TqMOlm3zqVzEe2su-D-7-PykdwOzrv84x9cMD30qxPXVP9Y12TdEpYXRAhVi38ld7mf</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Yoshikawa, Takahiro</creator><creator>Kanazawa, Hiroshi</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma</title><author>Yoshikawa, Takahiro ; Kanazawa, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-38e7c697101bca2bc11fb5550b06aa80de1a6a3ba3cdabf4bbf63a4348e8abcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Airway narrowing</topic><topic>Animals</topic><topic>Asthma - genetics</topic><topic>Asthma - immunology</topic><topic>Asthma - physiopathology</topic><topic>Asymptomatic airway hyperresponsiveness (AHR)</topic><topic>Biological and medical sciences</topic><topic>Bronchial asthma</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Clinical remission</topic><topic>Dyspnea - etiology</topic><topic>Dyspnea - physiopathology</topic><topic>Female</topic><topic>Forced Expiratory Volume - physiology</topic><topic>House dust mites</topic><topic>Humans</topic><topic>Immunoglobulin E - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Perception of dyspnea</topic><topic>Phenotype</topic><topic>Pneumology</topic><topic>Pulmonary/Respiratory</topic><topic>Pyroglyphidae - immunology</topic><topic>Remission, Spontaneous</topic><topic>Respiratory Hypersensitivity - genetics</topic><topic>Respiratory Hypersensitivity - immunology</topic><topic>Respiratory Hypersensitivity - physiopathology</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Spirometry</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshikawa, Takahiro</creatorcontrib><creatorcontrib>Kanazawa, Hiroshi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshikawa, Takahiro</au><au>Kanazawa, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>105</volume><issue>1</issue><spage>24</spage><epage>30</epage><pages>24-30</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Summary Background The present study aimed to illustrate differences in characteristics and perception of dyspnea between young atopic adults who have no history of asthma ( never -asthmatics) with or without asymptomatic airway hyperresponsiveness (AHR) and those who had childhood asthma and consider themselves to be grown out of the disease ( past -asthmatics). Methods Blood parameters, lung function and methacholine PC20 were measured in 88 never -asthmatics and 24 past -asthmatics. A perception score of dyspnea at 20% fall in FEV1 (PS20 ) was obtained by interpolation of the two last points on the perception (modified Borg scale)/fall in FEV1 curve during methacholine challenge. Results Thirty-one of 88 never -asthmatics and eighteen of 24 past -asthmatics exhibited AHR (PC20 was <8 mg/ml). Higher levels of specific IgE to house dust mite in past -asthmatics were observed than never -asthmatics with and without AHR. Mean values of FEV1 and FEF25–75 (%predicted) were significantly lower in past -asthmatics than never -asthmatics without AHR, and the values in never -asthmatics with AHR were intermediate between never -asthmatics without AHR and past -asthmatics. PC20 was not significantly different between past -asthmatics and never -asthmatics with AHR. Of particular interest was that PS20 was significantly lower in never -asthmatics with AHR compared with past -asthmatics. Conclusion The present findings suggest the possibilities that presence or absence of past history of outgrow of childhood asthma might be associated with airway narrowing, sensitization to house dust mite and perception of dyspnea in young asymptomatic adults with atopy and AHR.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20708396</pmid><doi>10.1016/j.rmed.2010.07.015</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Airway narrowing Animals Asthma - genetics Asthma - immunology Asthma - physiopathology Asymptomatic airway hyperresponsiveness (AHR) Biological and medical sciences Bronchial asthma Chronic obstructive pulmonary disease, asthma Clinical remission Dyspnea - etiology Dyspnea - physiopathology Female Forced Expiratory Volume - physiology House dust mites Humans Immunoglobulin E - immunology Male Medical sciences Perception of dyspnea Phenotype Pneumology Pulmonary/Respiratory Pyroglyphidae - immunology Remission, Spontaneous Respiratory Hypersensitivity - genetics Respiratory Hypersensitivity - immunology Respiratory Hypersensitivity - physiopathology Respiratory system : syndromes and miscellaneous diseases Spirometry Young Adult |
| title | Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma |
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