Evidence for Individual Human Peripheral Blood Lymphocytes bearing both B and T Cell Markers

LYMPHOCYTES are composed of two main populations: thymus-derived (T) lymphocytes which are largely responsible for cell-mediated immunity, and bursal-equivalent or bone-marrow derived (B) lymphocytes which are primarily involved in humoral immunity. B cells can be identified by the presence of fluor...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1974-01, Vol.247 (5438), p.213-215
Main Authors: DICKLER, H. B, ADKINSON, N. F, TERRY, W. D
Format: Article
Language:English
Subjects:
Antigen-Antibody Reactions - drug effects
B-Lymphocytes - immunology
Cell Membrane - immunology
Clone Cells
Humanities and Social Sciences
Humans
Immune Adherence Reaction
Immunoglobulins - analysis
Lectins
letter
Leukemia, Lymphoid - immunology
Lymphocyte Activation
Lymphocytes - immunology
Microscopy, Phase-Contrast
multidisciplinary
Neuraminidase - pharmacology
Science
Science (multidisciplinary)
T-Lymphocytes - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:LYMPHOCYTES are composed of two main populations: thymus-derived (T) lymphocytes which are largely responsible for cell-mediated immunity, and bursal-equivalent or bone-marrow derived (B) lymphocytes which are primarily involved in humoral immunity. B cells can be identified by the presence of fluorescence-detectable surface immunoglobulin 1–3 and by their ability to bind antigen-antibody complexes or heat-aggregated immunoglobulin through the Fc portion of the immunoglobulin molecule 4–7 . Human T cells can be identified by their ability to form non-immune rosettes (E rosettes) with sheep red blood cells (SRBC) 8–12 . We report here that when these B and T cell markers were evaluated simultaneously oh individual cells, a small subpopulation reproducibly bore both markers. Further experiments seemed to rule out artefact as an explanation.
ISSN:0028-0836
1476-4687
DOI:10.1038/247213a0