Haemophilus influenzae Meningitis in Infant Rats after Intranasal Inoculation

An animal model permitting study of bacterial meningitis has been developed in infant rats by the intranasal inoculation of Haemophilus influenzae b. Seventy-three percent (29 of 40) of five-day-old animals were bacteremic 48 hr after inoculation with 107 H. influenzae b; of those with bacteremia, 7...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1974-02, Vol.129 (2), p.154-162
Main Authors: Moxon, E. R., Smith, A. L., Averill, D. R., Smith, D. H.
Format: Article
Language:English
Subjects:
Animals
Bacteremia
Bacteria
Bacterial meningitis
Brain - microbiology
Disease Models, Animal
Dura Mater - pathology
Fluorescent Antibody Technique
Haemophilus influenzae
Haemophilus meningitis
Histology
Injections
Inoculation
Major Articles
Meninges - pathology
Meningitis, Haemophilus - etiology
Meningitis, Haemophilus - microbiology
Meningitis, Haemophilus - mortality
Meningitis, Haemophilus - pathology
Meningococcal meningitis
Methods
Nasal Mucosa - microbiology
Pneumococcal meningitis
Rats
Respiratory Tract Infections - complications
Sepsis - complications
Sepsis - etiology
Viral meningitis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An animal model permitting study of bacterial meningitis has been developed in infant rats by the intranasal inoculation of Haemophilus influenzae b. Seventy-three percent (29 of 40) of five-day-old animals were bacteremic 48 hr after inoculation with 107 H. influenzae b; of those with bacteremia, 79% had documented meningitis. Studies with fluorescein-labeled specific antiserum suggested that bacteria were dispersed in the upper respiratory tract, penetrated the nasal mucosa, entered the systemic circulation, and spread to the meninges from the dorsal longitudinal and lateral dural sinuses. The histologic appearance of the meningitis in infant rats was similar to that reported from specimens taken at human autopsy.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/129.2.154