Impact of Changes in Obesity Parameters on Glucose Metabolism and Insulin Resistance Over a One-Year Period

Aim: Changes in indexes of obesity, such as waist circumference (WC) and body mass index (BMI), may influence some glucose metabolism-related parameters in both obese and non-obese subjects. We have investigated the impact of changes in WC and in BMI on data related to glucose metabolism over a one-...

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Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2010, Vol.17(12), pp.1246-1255
Main Authors: Sakamoto, Aiko, Ishizaka, Yuko, Toda, Ei-Ichi, Nagai, Ryozo, Koike, Kazuhiko, Yamakado, Minoru, Ishizaka, Nobukazu
Format: Article
Language:English
Subjects:
Body Mass Index
Female
Glucose - metabolism
Health screening
Humans
Insulin Resistance
Male
Middle Aged
Obesity - metabolism
Sex Factors
Waist Circumference
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Summary:Aim: Changes in indexes of obesity, such as waist circumference (WC) and body mass index (BMI), may influence some glucose metabolism-related parameters in both obese and non-obese subjects. We have investigated the impact of changes in WC and in BMI on data related to glucose metabolism over a one-year period. Methods: Data from 3213 individuals (2014 men, 1199 women) who underwent a general health screening two years running and were not taking antidiabetic medication were analyzed. Results: In men, percent changes in WC (%dWC) and BMI (%dBMI) were both significantly correlated with percent changes in fasting glucose (%dFG), in hemoglobin A1C (%dHbA1C), and in HOMA-IR (%dHOMA-IR). In women, these relationships were not significant except for the relationship between %dBMI and %dHOMA-IR. In a multivariate linear regression analysis using age, %dBMI, and %dWC as independent variables, %dBMI, but not %dWC, was found to be an independent predictor of %dHOMA-IR in both genders. Furthermore, in men, %dBMI was also an independent factor predicting %dFG and %dHbA1C. Conclusion: During the one-year period, a reduction in BMI, and thus weight loss, was found to be associated with the improvement of insulin sensitivity, especially in men. A reduction in WC was also associated with an improvement in insulin sensitivity in men; however, this relationship did not remain significant after controlling for changes in BMI.
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.5959