Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy

Allergic sensitization to cat allergens is common and represents a major risk factor for asthma. Specific immunotherapy (SIT) is effective but cumbersome and associated with IgE-dependent adverse events. Immunotherapy targeting allergen-specific T cells, with synthetic peptides representing T-cell e...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology 2011, Vol.127 (1), p.89-97.e14
Main Authors:	Worm, Margitta, Lee, Hae-Hyuk, Kleine-Tebbe, Jörg, Hafner, Roderick P., Laidler, Paul, Healey, David, Buhot, Cecile, Verhoef, Adrienne, Maillère, Bernard, Kay, A. Barry, Larché, Mark
Format:	Article
Language:	English
Subjects:	allergens Allergies allergy Allergy and Immunology Amino Acid Sequence Animals Asthma basophils binding capacity Biological and medical sciences Cats clinical trials Double-Blind Method epitope Epitopes, T-Lymphocyte - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Glycoproteins - immunology Glycoproteins - therapeutic use Good Manufacturing Practice histamine HLA-DR Antigens Humans Hypersensitivity - immunology Hypersensitivity - prevention & control immune tolerance Immunodominant Epitopes Immunopathology Immunotherapy Immunotherapy - methods interferon-gamma interleukin-10 interleukin-13 Medical sciences Methods MHC Molecular Sequence Data peptide Peptides risk factors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis secretion Skin Studies synthetic peptides T cell T-lymphocytes vaccine vaccines Vaccines, Subunit - immunology Vaccines, Subunit - therapeutic use
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