Transmission of Rat Virus in Milk of Rats

Search for a model that might aid in the study of transmission of viruses in the milk of man or other animals has led to the finding that rat virus is shed in the milk of rats in substantial amounts after inoculation on the second day of lactation. Harvests made on successive days after inoculation...

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Bibliographic Details
Published in:The Journal of infectious diseases 1974-06, Vol.129 (6), p.737-740
Main Authors: Kilham, Lawrence, Margolis, George
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - analysis
Blood
Blood - microbiology
Culture Techniques
Disease Models, Animal
Disease Susceptibility
Disease transmission
Female
Hemagglutination Inhibition Tests
Infections
Inoculation
Lactation
Mammary glands
Mammary Glands, Animal - immunology
Mammary Glands, Animal - microbiology
Milk - immunology
Milk - microbiology
Parvoviridae - immunology
Pregnancy
Rats
Rats - embryology
Salivary glands
Salivary Glands - immunology
Salivary Glands - microbiology
Stomach
Suckling
Virus Diseases - immunology
Virus Diseases - microbiology
Virus Replication
Viruses
Viruses - growth & development
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Summary:Search for a model that might aid in the study of transmission of viruses in the milk of man or other animals has led to the finding that rat virus is shed in the milk of rats in substantial amounts after inoculation on the second day of lactation. Harvests made on successive days after inoculation showed that whole blood, mammary glands, and milk removed from the stomachs of sucklings all had infectivity titers of approximately 10−3–10−4/0.1 ml when tested in rat embryo tissue cultures. Rat virus continued to be recoverable for a number of days after the appearance of circulating (HAI) antibodies. Proliferation of virus in mammary tissue and excretion of virus brought to the gland by the bloodstream are postulated to have been the chief mechanisms involved in the virolactia.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/129.6.737