Ventricular Pressure-Volume Relationships and Oxygen Consumption in Fibrillation and Arrest

Pressure-volume relationships and myocardial oxygen consumption (V˙O2) were obtnined in an isolated heart during ventricular fibrillation, potassium-induced arrest, and isovolumetric contractions. The heart was found to be less distensible in fibrillation than in diastole or arrest. The V˙O2 increas...

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Bibliographic Details
Published in:Circulation research 1960-01, Vol.8 (1), p.260-266
Main Authors: Monroe, R Grier, French, Gordon
Format: Article
Language:English
Subjects:
Arrhythmias, Cardiac
Brugada Syndrome
Cardiac Conduction System Disease
Heart Arrest
Heart Conduction System
Humans
Metabolism
Old Medline
Oxygen Consumption
Ventricular Fibrillation
Ventricular Pressure
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Summary:Pressure-volume relationships and myocardial oxygen consumption (V˙O2) were obtnined in an isolated heart during ventricular fibrillation, potassium-induced arrest, and isovolumetric contractions. The heart was found to be less distensible in fibrillation than in diastole or arrest. The V˙O2 increased from 4.6 to 14.6 cc./100 Gm. LV/min. as the fibrillating ventricle was distended. During arrest the V˙O2 remained constant despite ventricular distention. When the fibrillating ventricle was distended beyond a critical point coronary flow was compromised and the V˙O2 decreased. Beyond and only beyond this point could the V˙O2 be increased by the greater coronary flow induced by a higher perfusion pressure.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.8.1.260