Nucleic Acids as Transplantation Antigens

MUCH has been written about the role of nucleic acids in transplantation immunity 1–3 . From previous work it has been concluded that deoxyribonucleic acid (DNA) was not antigenic. The following results, based on chemical analysis including chromatography of sugars 4 and of purines and pyrimidines o...

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Bibliographic Details
Published in:Nature (London) 1961-02, Vol.189 (4763), p.504-505
Main Author: CASTERMANS, ANDRÉ
Format: Article
Language:English
Subjects:
Antigens
Histocompatibility Antigens
Humanities and Social Sciences
letter
multidisciplinary
Nucleic Acids
Old Medline
Science
Science (multidisciplinary)
Transplantation Immunology
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Summary:MUCH has been written about the role of nucleic acids in transplantation immunity 1–3 . From previous work it has been concluded that deoxyribonucleic acid (DNA) was not antigenic. The following results, based on chemical analysis including chromatography of sugars 4 and of purines and pyrimidines or their derivatives, suggest that ribonucleic acid (RNA) also is not a necessary part of the antigenic molecule. Antigens from mouse spleen and thymus were prepared by different procedures 5–7 . Their antigenicity was checked by techniques previously described 3 .
ISSN:0028-0836
1476-4687
DOI:10.1038/189504a0