The Magnesium Load Test: II. Correlation of Clinical and Laboratory Data in Neonates

Parenteral magnesium load tests were con ducted on 91 infants less than one month of age, most of whom had marked hyperirritability and symptoms compatible with the diagnosis of electrolyte imbalance with relative or absolute magnesium deficiency. Most of the patients studied had a 40-hour test, wit...

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Bibliographic Details
Published in:Clinical pediatrics 1975-05, Vol.14 (5), p.460-465
Main Authors: Byrne, Paul A., Caddell, Joan L.
Format: Article
Language:English
Subjects:
Calcium - blood
Calcium - metabolism
Female
Humans
Hypocalcemia - metabolism
Infant, Newborn
Infant, Premature
Injections, Intramuscular
Magnesium - blood
Magnesium - metabolism
Magnesium - therapeutic use
Magnesium Deficiency - drug therapy
Magnesium Deficiency - metabolism
Male
Sex Factors
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Summary:Parenteral magnesium load tests were con ducted on 91 infants less than one month of age, most of whom had marked hyperirritability and symptoms compatible with the diagnosis of electrolyte imbalance with relative or absolute magnesium deficiency. Most of the patients studied had a 40-hour test, with an eight-hour preload and a 32-hour postload collection of urine. Of 43 premature infants studied, only three retained less than 40 per cent of the load: one was untreated, one had low retention of a second load following a course of therapy, and the mother of the third had received magnesium within 24 hours of delivery. Of 48 full-term infants studied, ten retained less than 40 per cent of the load. These were asymptomatic or had minor problems. Irritability was common in both high and low retention groups. Ten per cent of the low retention group and 50 per cent of the high retention group manifested two or more of the nonspecific signs compatible with the diagnosis of magnesium deficiency; the difference was significant (P
ISSN:0009-9228
1938-2707
DOI:10.1177/000992287501400505