Biopharmaceutic Factors in Parenteral Administration of Vitamin E

When properly formulated, micellar‐type aqueous dispersions of tocopheryl acetate are administered intravenously or intramuscularly to dogs, the rate‐limiting step in the bioavailability of the physiologically active free tocopherol is the rate of hydrolysis of the acetate ester. A similar dispersio...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1975-04, Vol.64 (4), p.655-657
Main Authors: Newmark, Harold L., Pool, William, Bauernfeind, Jacob C., De Ritter, Elmer
Format: Article
Language:English
Subjects:
Acetates - metabolism
Animals
Bioavailability-tocopheryl acetate from parenteral formulations
Biopharmaceutics
Dogs
Emulsions
Humans
Infusions, Parenteral
Injections, Intramuscular
Injections, Intravenous
parenteral administration
rate-limiting step
Time Factors
Tocopheryl acetate-biopharmaceutic factors
Tocopheryl acetate—biopharmaceutic factors, parenteral administration, rate‐limiting ste
Tocopheryl acetate—biopharmaceutic factors, parenteral administration, rate‐limiting step
Vitamin E - administration & dosage
Vitamin E - metabolism
Vitamin E-biopharmaceutic factors
Vitamin E—biopharmaceutic factors, parenteral administration, rate‐limiting step
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Description
Summary:When properly formulated, micellar‐type aqueous dispersions of tocopheryl acetate are administered intravenously or intramuscularly to dogs, the rate‐limiting step in the bioavailability of the physiologically active free tocopherol is the rate of hydrolysis of the acetate ester. A similar dispersion of free tocopherol yields blood levels of tocopherol many fold higher than those obtained with the acetate ester after intravenous injection and also yields much greater increases in blood levels of free tocopherol after intramuscular injection than the acetate ester formulation, particularly in the early period after the dose.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600640418