Altering iodine metabolism in the calf by feeding iodine-binding agents

• Published in: Journal of dairy science 1975-06, Vol.58 (6), p.931-937
• Main Authors: Miller, J.K, Swanson, E.W, Lyke, W.A, Byrne, W.F
• Format: Article
• Language: English
• Subjects: Administration, Oral; Animals; Anion Exchange Resins - pharmacology; Cattle - metabolism; cottonseed meal; Cottonseed Oil - pharmacology; Digestive System - metabolism; Dose-Response Relationship, Drug; Feces - analysis; Injections, Intravenous; Injections, Subcutaneous; Iodine - metabolism; Iodine Radioisotopes - administration & dosage; Ion Exchange Resins - pharmacology
• ISSN: 0022-0302; 1525-3198
• DOI: 10.3168/jds.S0022-0302(75)84659-5

Effects of feeding cottonseed meal and anion-exchange resin on iodine absorption and excretion by calves were investigated. Each additional amount of resin fed from .3 to 3.5 g/kg body weight further increased fecal excretion from single oral iodine-131 and intravenous iodine-125 doses. By feeding 3 to 10 g cottonseed meal/kg body weight, excretion of oral iodine-131 given daily was increased 7 to 94% in feces and reduced as much as 35% in urine, but plasma iodine-131 was not changed. Introducing 1 g resin/kg body weight daily into the diet increased fecal iodine-131 excretion three to five times that with cottonseed meal alone and reduced both plasma and urinary iodine-131. The same amount of resin fed daily had similar effects on excretion of iodine-131 injected subcutaneously each day. Although iodine depletion by a highly efficient iodine binder (resin) in the gastrointestinal tract is probable, iodine binding by a natural feed constituent (cottonseed meal) was relatively inefficient.