Effect of Sulfate Content of Several Anionic Polymers on in Vitro Activity of Pepsin

Carrageenan was degraded with acid to give materials with sulfate contents varying from 5–30%. Antipeptic activities of these materials correlated closely with the sulfate content. Other sulfated polymers such as polyvinyl sulfonate, sulfated rice starch, amylose sulfate, heparin, etc., gave a simil...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1962-09, Vol.51 (9), p.857-860
Main Authors: Ravin, L.J., Baldinus, J.G., Mazur, M.L.
Format: Article
Language:English
Subjects:
Anions
In Vitro Techniques
Ions
Old Medline
Pepsin A - antagonists & inhibitors
Polymers - pharmacology
Polyvinyls - pharmacology
Sulfates - pharmacology
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Summary:Carrageenan was degraded with acid to give materials with sulfate contents varying from 5–30%. Antipeptic activities of these materials correlated closely with the sulfate content. Other sulfated polymers such as polyvinyl sulfonate, sulfated rice starch, amylose sulfate, heparin, etc., gave a similar correlation. All these polymers precipitated protein in the antipeptic test. Compounds such as sodium lauryl sulfate and m-xylene sulfonate possessed significant antipeptic activity but did not precipitate protein, and no correlation between sulfate content and antipeptic activity was found. The precipitation of protein by carrageenan depends upon the pH, becoming negligible at a pH above 4.5.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600510909